ArticleScientific reports2013
High-power femtosecond-terahertz pulse induces a wound response in mouse skin.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Non-Thermal Effects of Terahertz Radiation on Gene Expression: Systematic Review and Meta-Analysis.Genes · 2024Pooled it
- Research Progress of Terahertz Technology in Microbiology.Biosensors · 2026Review
- 3.75 THz Repetitive Radiation Regulates Collagen Metabolism in Human Fetal Scleral Fibroblasts.Cells · 2026Article
- Review
- Article
- Transcriptomic Analysis of Blood Collagen-Induced Arthritis Mice Exposed to 0.1 THz Reveals Inhibition of Genes and Pathways Involved in Rheumatoid Arthritis.International journal of molecular sciences · 2024Article
- Anti-Inflammatory and Immunomodulatory Effects of 0.1 Sub-Terahertz Irradiation in Collagen-Induced Arthritis Mice.International journal of molecular sciences · 2024Article
- Article
- The biological effects of terahertz wave radiation-induced injury on neural stem cells.iScience · 2023Article
- Review
- Body-Centric Terahertz Networks: Prospects and Challenges.IEEE transactions on molecular, biological, and multi-scale communications · 2022Article
- In Vivo Assessment and Monitoring of Burn Wounds Using a Handheld Terahertz Hyperspectral Scanner.Advanced photonics research · 2022Article
- Transcriptome profiling of guinea pig skin exposed to a high-power terahertz source.Environmental and molecular mutagenesis · 2022Article
- Advances of terahertz technology in neuroscience: Current status and a future perspective.iScience · 2021Review
- Cellular effects of terahertz waves.Journal of biomedical optics · 2021Review
- Terahertz pulses induce segment renewal via cell proliferation and differentiation overriding the endogenous regeneration program of the earthwormBiomedical optics express · 2021Article
- Terahertz radiation and the skin: a review.Journal of biomedical optics · 2021Review
- Fluorescent bacterial biosensorBiomedical optics express · 2021Article
- Article
- Study on the effects of terahertz radiation on gene networks ofBiomedical optics express · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Terahertz (THz) technology has emerged for biomedical applications such as scanning, molecular spectroscopy, and medical imaging. Although a thorough assessment to predict potential concerns has to precede before practical utilization of THz source, the biological effect of THz radiation is not yet fully understood with scant related investigations. Here, we applied a femtosecond-terahertz (fs-THz) pulse to mouse skin to evaluate non-thermal effects of THz radiation. Analysis of the genome-wide expression profile in fs-THz-irradiated skin indicated that wound responses were predominantly mediated by transforming growth factor-beta (TGF-β) signaling pathways. We validated NFκB1- and Smad3/4-mediated transcriptional activation in fs-THz-irradiated skin by chromatin immunoprecipitation assay. Repeated fs-THz radiation delayed the closure of mouse skin punch wounds due to up-regulation of TGF-β. These findings suggest that fs-THz radiation initiate a wound-like signal in skin with increased expression of TGF-β and activation of its downstream target genes, which perturbs the wound healing process in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.