Trial reportIntensive care medicine2013
The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome.
Trial report in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
264 citing papers in PubMed, 10 syntheses or guidelines pooled it, 572 citations in OpenAlex.
- Early Prediction of Mortality Risk in Acute Respiratory Distress Syndrome: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Role of age as eligibility criterion for ECMO in patients with ARDS: meta-regression analysis.Critical care (London, England) · 2024Pooled it
- Long-term outcomes of patients supported with extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis.Intensive care medicine · 2024Pooled it
- Long-Term Neuropsychiatric, Neurocognitive, and Functional Outcomes of Patients Receiving ECMO: A Systematic Review and Meta-AnalysisNeurology · 2024Pooled it
- Predictive models in extracorporeal membrane oxygenation (ECMO): a systematic review.Systematic reviews · 2023Pooled it
- Prognostic models for mortality risk in patients requiring ECMO.Intensive care medicine · 2023Pooled it
- Quality of life following adult veno-venous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Pooled it
- ECMO for severe ARDS: systematic review and individual patient data meta-analysis.Intensive care medicine · 2020Pooled it
- Determinants of Quality of Life and Return to Work Following Acute Respiratory Distress Syndrome.Deutsches Arzteblatt international · 2017Pooled it
- Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis : Mechanical ventilation during ECMO.Intensive care medicine · 2016Pooled it
- Pre-cannulation ventilation duration and the trajectory of venovenous extracorporeal membrane oxygenation in COVID-19-related acute respiratory distress syndrome: a nationwide competing-risks cohort study.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Article
- Post-traumatic stress disorder following intensive care for COVID-19: a single-center retrospective follow-up study.BMC anesthesiology · 2026Article
- The Acute Respiratory Distress Syndrome (ARDS): epidemiology, etiology, molecular mechanisms, diagnosis and therapeutic strategies.Molecular biomedicine · 2026Review
- Association of Plasma Biomarkers of Immunothrombosis With Death in Patients With Coronavirus Disease 2019 on Extracorporeal Membrane Oxygenation.The Journal of infectious diseases · 2026Article
- ECMO for patients with obesity: evidence and practice.Intensive care medicine · 2026Review
- Association of prolonged pre-intubation high-flow nasal cannula duration with survival and successful V-V ECMO liberation in severe ARDS: a retrospective multicenter study.Journal of intensive care · 2026Article
- Comparison of Midazolam Plasma Concentrations in ARDS Patients with and Without ECMO Support-Prospective Observational Pilot Study.Life (Basel, Switzerland) · 2026Article
- Patient outcomes following extracorporeal membrane oxygenation support for severe COVID-19 acute respiratory distress syndrome.Proceedings (Baylor University. Medical Center) · 2026Article
- How to optimize brain perfusion and prevent cerebral complications during extracorporeal life support.Intensive care medicine · 2026Review
- Drug Monitoring of Therapy with Midazolam in Patients with ARDS: A Single-Center Prospective Study.Medicina (Kaunas, Lithuania) · 2026Article
204 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was designed to identify factors associated with death by 6 months post-intensive care unit (ICU) discharge and to develop a practical mortality risk score for extracorporeal membrane oxygenation (ECMO)-treated acute respiratory distress syndrome (ARDS) patients. We also assessed long-term survivors' health-related quality of life (HRQL), respiratory symptoms, and anxiety, depression and post-traumatic stress disorder (PTSD) frequencies.
methodsData from 140 ECMO-treated ARDS patients admitted to three French ICUs (2008-2012) were analyzed. ICU survivors contacted >6 months post-ICU discharge were assessed for HRQL, psychological and PTSD status.
resultsMain ARDS etiologies were bacterial (45%), influenza A[H₁N₁] (26%) and post-operative (17%) pneumonias. Six months post-ICU discharge, 84 (60%) patients were still alive. Based on multivariable logistic regression analysis, the PRESERVE (PRedicting dEath for SEvere ARDS on VV-ECMO) score (0-14 points) was constructed with eight pre-ECMO parameters, i.e. age, body mass index, immunocompromised status, prone positioning, days of mechanical ventilation, sepsis-related organ failure assessment, plateau pressure andpositive end-expiratory pressure. Six-month post-ECMO initiation cumulative probabilities of survival were 97, 79, 54 and 16% for PRESERVE classes 0-2, 3-4, 5-6 and ≥7 (p < 0.001), respectively. HRQL evaluation in 80% of the 6-month survivors revealed satisfactory mental health but persistent physical and emotional-related difficulties, with anxiety, depression or PTSD symptoms reported, by 34, 25 or 16%, respectively.
conclusionsThe PRESERVE score might help ICU physicians select appropriate candidates for ECMO among severe ARDS patients. Future studies should also focus on physical and psychosocial rehabilitation that could lead to improved HRQL in this population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.