ArticleIntensive care medicine2013
Impact of chronic liver disease in intensive care unit acquired pneumonia: a prospective study.
Article in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03413293 (Nosocomial Bacterial and Fungal Chest Infections in Cirrhotic Patients), which is not on this map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nosocomial Bacterial and Fungal Chest Infections in Cirrhotic Patients
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- SOFA-2 Score and Mortality in Suspected Infection Stratified by Cirrhosis Status: A Multi-Institutional Observational Cohort Study.Liver international : official journal of the International Association for the Study of the Liver · 2026Observational
- Burden and Impact of Pneumococcal Pneumonia on Outcomes in Patients With Cirrhosis: A Nationwide Analysis.Gastroenterology research · 2026Article
- Factors Associated with Mortality in Nosocomial Lower Respiratory Tract Infections: An ENIRRI Analysis.Antibiotics (Basel, Switzerland) · 2025Article
- Adverse Outcomes of Patients with Non-Ventilator-Associated Hospital-Acquired Pneumonia (nvHAP)-A Single Centre Cohort Study.Infectious disease reports · 2024Article
- Are Cirrhotic Patients Receiving Invasive Mechanical Ventilation at Risk of Abundant Microaspiration.Journal of clinical medicine · 2022Article
- Liver stiffness is associated with disease severity and worse clinical scenarios in coronavirus disease 2019: A prospective transient elastography study.International journal of clinical practice · 2021Article
- Chronic liver disease is not associated with severity or mortality in Coronavirus disease 2019 (COVID-19): a pooled analysis.European journal of gastroenterology & hepatology · 2021Article
- Lymphocytopenia as a Predictor of Mortality in Patients with ICU-Acquired Pneumonia.Journal of clinical medicine · 2019Article
- Effect of combination of pre- and postoperative pulmonary rehabilitation on onset of postoperative pneumonia: a retrospective cohort study based on data from the diagnosis procedure combination database in Japan.International journal of clinical oncology · 2019Article
- Pneumonia in patients with cirrhosis: risk factors associated with mortality and predictive value of prognostic models.Respiratory research · 2018Article
- Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery for head and neck cancer.Frontiers of medicine · 2017Article
- Hepatosplanchnic circulation in cirrhosis and sepsis.World journal of gastroenterology · 2015Review
- Year in review in Intensive Care Medicine 2013: III. Sepsis, infections, respiratory diseases, pediatrics.Intensive care medicine · 2014Article
- Risk factors and outcome of bacterial infections in cirrhosis.World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the impact of chronic liver disease (CLD) on ICU-acquired pneumonia.
methodsThis was a prospective, observational study of the characteristics, microbiology, and outcomes of 343 consecutive patients with ICU-acquired pneumonia clustered according to the presence of CLD.
resultsSixty-seven (20%) patients had CLD (67% had liver cirrhosis, LC), MELD score 26 ± 9, 20% Child-Pugh class C). They presented higher severity scores than patients without CLD both on admission to the ICU (APACHE II, LC 19 ± 6 vs. other CLD 18 ± 6 vs. no CLD 16 ± 6; p < 0.001; SOFA, 10 ± 3 vs. 8 ± 4 vs. 7 ± 3; p < 0.001) and at onset of pneumonia (APACHE II, 19 ± 6 vs. 17 ± 6 vs. 16 ± 5; p = 0.001; SOFA, 11 ± 4 vs. 9 ± 4 vs. 7 ± 3; p < 0.001). Levels of CRP were lower in patients with LC than in the other two groups (day 1, 6.5 [2.5-11.5] vs. 13 [6-23] vs. 15.5 [8-24], p < 0.001, day 3, 6 [3-12] vs. 16 [9-21] vs. 11 [5-20], p = 0.001); all the other biomarkers were higher in LC and other CLD patients. LC patients had higher 28- and 90-day mortality (63 vs. 28%, p < 0.001; 72 vs. 38%, p < 0.001, respectively) than non-CLD patients. Presence of LC was independently associated with decreased 28- and 90-day survival (95% confidence interval [CI], 1.982-17.250; p = 0.001; 95% confidence interval [CI], 2.915-20.699, p = 0.001, respectively).
conclusionsIn critically ill patients with ICU-acquired pneumonia, CLD is associated with a more severe clinical presentation and poor clinical outcomes. Moreover, LC is independently associated with 28- and 90-day mortality. The results of this study are important for future trials focused on mortality.
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