ArticleMolecular imaging and biology2014
Magnetomotive optical coherence tomography for the assessment of atherosclerotic lesions using αvβ3 integrin-targeted microspheres.
Article in Molecular imaging and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Magnetic particles in motion: magneto-motive imaging and sensing.Theranostics · 2022Review
- Optical coherence elastography - OCT at work in tissue biomechanics [Invited].Biomedical optics express · 2017Review
- Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas.Journal of biophotonics · 2016Article
- Enhancement and wavelength-shifted emission of Cerenkov luminescence using multifunctional microspheres.Physics in medicine and biology · 2015Article
- Volumetric full-range magnetomotive optical coherence tomography.Journal of biomedical optics · 2014Article
- Magnetomotive optical coherence elastography using magnetic particles to induce mechanical waves.Biomedical optics express · 2014Article
- Molecular Imaging in Optical Coherence Tomography.Current molecular imaging · 2014Article
- Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
- Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeWe investigated the early-stage fatty streaks/plaques detection using magnetomotive optical coherence tomography (MM-OCT) in conjunction with αvβ3 integrin-targeted magnetic microspheres (MSs). The targeting of functionalized MSs was investigated by perfusing ex vivo aortas from an atherosclerotic rabbit model in a custom-designed flow chamber at physiologically relevant pulsatile flow rates and pressures. PROCEDURES: Aortas were extracted and placed in a flow chamber. Magnetic MS contrast agents were perfused through the aortas and MM-OCT, fluorescence confocal, and bright field microscopy were performed on the ex vivo aorta specimens for localizing the MSs.
resultsThe results showed a statistically significant and stronger MM-OCT signal (3.30 ± 1.73 dB) from the aorta segment perfused with targeted MSs, compared with the nontargeted MSs (1.18 ± 0.94 dB) and control (0.78 ± 0.41 dB) aortas. In addition, there was a good co-registration of MM-OCT signals with confocal microscopy.
conclusionsEarly-stage fatty streaks/plaques have been successfully detected using MM-OCT in conjunction with αvβ3 integrin-targeted magnetic MSs.
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Registered trials
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