mTOR, AMBRA1, and autophagy: an intricate relationship.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

24 citing papers in PubMed.

1. Orchestration of Autophagy and Senescence: Kinases Take the Center Stage.Cells · 2026
   Review
2. Inhibiting autophagy enhances anti-cancer properties of sulforaphane.Scientific reports · 2026
   Article
3. Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment.Frontiers in immunology · 2024
   Review
4. Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation.Nature communications · 2023
   Article
5. Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage.Life (Basel, Switzerland) · 2022
   Article
6. The ménage à trois of autophagy, lipid droplets and liver disease.Autophagy · 2022
   Review
7. Natural Products in Therapeutic Management of Multineurodegenerative Disorders by Targeting Autophagy.Oxidative medicine and cellular longevity · 2021
   Review
8. Ambra1 Alleviates Hypoxia/Reoxygenation Injury in H9C2 Cells by Regulating Autophagy and Reactive Oxygen Species.BioMed research international · 2020
   Article
9. Skeletal muscle: A review of molecular structure and function, in health and disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2020
   Review
10. GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia.Autophagy · 2019
    Article
11. Neurodevelopmental Disorders: Functional Role of Ambra1 in Autism and Schizophrenia.Molecular neurobiology · 2019
    Review
12. USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy.Autophagy · 2019
    Article
13. Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.Autophagy · 2019
    Article
14. AMBRA1, Autophagy, and the Extreme Male Brain Theory of Autism.Autism research and treatment · 2019
    Article
15. NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer.Cell cycle (Georgetown, Tex.) · 2017
    Article
16. More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy.International journal of molecular sciences · 2017
    Review
17. The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders.Oxidative medicine and cellular longevity · 2017
    Review
18. Oxidative stress and autophagy: the clash between damage and metabolic needs.Cell death and differentiation · 2015
    Review
19. Key autophagic targets and relevant small-molecule compounds in cancer therapy.Cell proliferation · 2015
    Review
20. Growing knowledge of the mTOR signaling network.Seminars in cell & developmental biology · 2014
    Review

Corrections and comments

• Comment on
  mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.2013

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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