ArticleCell cycle (Georgetown, Tex.)2013
NOTCH signaling in Sertoli cells regulates gonocyte fate.
Article in Cell cycle (Georgetown, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
- Comparison of Sertoli cells in duck testes pre- and post-sexual maturation.Poultry science · 2026Article
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- Update of the scientific opinion on tetrabromobisphenol A (TBBPA) and its derivatives in food.EFSA journal. European Food Safety Authority · 2024Article
- Characterization of expression patterns and dynamic relocation of Notch proteins during acrosome reaction of bull spermatozoa.Scientific reports · 2024Article
- Notch pathway is required for protection against heat stress in spermatogonial stem cells in medaka.Fish physiology and biochemistry · 2023Article
- Assessment of Zearalenone-Induced Cell Survival and of Global Gene Regulation in Mouse TM4 Sertoli Cells.Toxins · 2022Article
- Sumoylation and its regulation in testicular Sertoli cells.Biochemical and biophysical research communications · 2021Article
- Cell-fate transition and determination analysis of mouse male germ cells throughout development.Nature communications · 2021Article
- Unexpected Interacting Effects of Physical (Radiation) and Chemical (Bisphenol A) Treatments on Male Reproductive Functions in Mice.International journal of molecular sciences · 2021Article
- Immune profiles of male giant panda (Ailuropoda melanoleuca) during the breeding season.BMC genomics · 2021Article
- Involvement of Cytokines and Hormones in the Development of Spermatogenesis In Vitro from Spermatogonial Cells of Cyclophosphamide-Treated Immature Mice.International journal of molecular sciences · 2021Article
- YY1 and CP2c in Unidirectional Spermatogenesis and Stemness.Development & reproduction · 2020Review
- Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.Reproductive biology and endocrinology : RB&E · 2020Article
- Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis.Cell death & disease · 2019Review
- Undifferentiated spermatogonia regulateFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Regulation of GDNF expression in Sertoli cells.Reproduction (Cambridge, England) · 2019Review
- Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males.Scientific reports · 2018Article
- Notch Signaling Regulates Differentiation and Steroidogenesis in Female Mouse Ovarian Granulosa Cells.Endocrinology · 2018Article
- The testicular transcriptome associated with spermatogonia differentiation initiated by gonadotrophin stimulation in the juvenile rhesus monkey (Macaca mulatta).Human reproduction (Oxford, England) · 2017Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Gonocytes (or prospermatogonia) are the precursors to spermatogonial stem cells (SSCs), which provide the foundation for spermatogenesis through their ability to both self-renew and generate daughter cells. Despite their relative importance, the regulatory mechanisms that govern gonocyte maintenance and transition to SSCs are poorly understood. Recently, we reported that constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence--the first suggestion of the potential role of this signaling pathway in the testis. This Extra View will review what is known about NOTCH signaling, particularly in Sertoli cells and germ cells in the testes, by providing a background on germ cell biology and a summary of our recently published data on NOTCH1 signaling in Sertoli cells. We also describe additional data showing that aberrant proliferation and differentiation of gonocytes in response to constitutive activation of NOTCH1 signaling in Sertoli cells involves de novo expression of cell cycle proteins and a marked upregulation of the KIT receptor. These data further suggest that NOTCH signaling orchestrates a dynamic balance between maintenance and differentiation of gonocytes in the perinatal testis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.