ArticleInternational clinical psychopharmacology2014
Association of DHEA, DHEAS, and cortisol with childhood trauma exposure and post-traumatic stress disorder.
Article in International clinical psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Trial
- Elevated cortisol/DHEA ratio mediates the association between symptom severity and working memory impairment in drug-naive, first-episode OCD.Frontiers in psychiatry · 2026Article
- The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications.Frontiers in neuroendocrinology · 2024Review
- Measuring adverse childhood experiences with latent class trajectories.Child abuse & neglect · 2023Article
- Traumatic Brain Injury Biomarkers, Simulations and Kinetics.Bioengineering (Basel, Switzerland) · 2022Article
- Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother-newborn dyads.Translational psychiatry · 2021Article
- Sex differences in the impact of childhood socioeconomic status on immune function.Scientific reports · 2021Observational
- Article
- Violence Victimization Predicts Body Mass Index One Decade Later among an Urban Sample of African American Young Adults: Sex as a Moderator and Dehydroepiandrosterone as a Mediator.Journal of urban health : bulletin of the New York Academy of Medicine · 2019Article
- The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach.Scientific reports · 2019Article
- Victims of War: Dehydroepiandrosterone Concentrations in Hair and Their Associations with Trauma Sequelae in Palestinian Adolescents Living in the West Bank.Brain sciences · 2019Article
- Attachment-Related Regulatory Processes Moderate the Impact of Adverse Childhood Experiences on Stress Reaction in Borderline Personality Disorder.Journal of personality disorders · 2018Article
- Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment.BMC psychiatry · 2017Article
- The impact of the severity of early life stress on diurnal cortisol: The role of puberty.Psychoneuroendocrinology · 2017Article
- Childhood abuse is associated with increased hair cortisol levels among urban pregnant women.Journal of epidemiology and community health · 2015Article
- Dimensions of Adversity, Physiological Reactivity, and Externalizing Psychopathology in Adolescence: Deprivation and Threat.Psychosomatic medicineArticle
- Maternal Lifetime Trauma Exposure, Prenatal Cortisol, and Infant Negative Affectivity.Infancy : the official journal of the International Society on Infant StudiesArticle
- Cortisol as a Biomarker of Alcohol Use in Combat Veterans: A Literature Review and Framework for Future Research.Journal of dual diagnosisReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
There has been a great deal of interest in the role of the neuroendocrine hormones of the hypothalamic-pituitary-adrenal (HPA) axis in the expression of stress-related psychopathology such as post-traumatic stress disorder (PTSD). This investigation examined the association of PTSD and childhood maltreatment with three key HPA axis hormones: cortisol, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEAS). Regression analyses were undertaken on a sample of 43 participants with and 57 participants without PTSD. Results demonstrated that after controlling for age, sex, and PTSD status, exposure to childhood maltreatment was significantly associated with cortisol secretion [F(4,95)=11.68, ΔR(2)=0.11, P=0.0009] and cortisol/DHEA ratio [F(4,95)=6.20, ΔR(2)=0.05, P=0.01]. PTSD status was not associated with any of these neuroendocrine variables. Findings are discussed in the context of the complexity of the relationship of these neuroendocrine variables with trauma exposure and trauma-related psychopathology. It is suggested that DHEA(S) or cortisol/DHEA(S) ratios may not be biomarkers of specific forms of psychopathology per se, but that, instead, the severity and developmental timing of trauma may set the HPA axis in ways that are reflected in interactions among these neuroendocrine hormones. In adulthood, these HPA axis hormones may continue to be dynamically affected by personal and environmental resources.
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Registered trials
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