Evidence map›Paper›PMID 23907010›Full record

ReviewFEBS letters2013

Direction of aminoacylated transfer RNAs into antibiotic synthesis and peptidoglycan-mediated antibiotic resistance.

Jennifer Shepherd, Michael Ibba

Abstract readReview
In one paragraph

Review in FEBS letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Proteomic Response ofLife (Basel, Switzerland) · 2021
    Article
  11. Article
  12. Article
  13. Metabolic Responses of a Model Green MicroalgaFrontiers in bioengineering and biotechnology · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Proteomic and Metabolomic Profiling ofFrontiers in microbiology · 2019
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer ShepherdDepartment of Microbiology and Center for RNA Biology, Ohio State University, Columbus, OH 43210-1292, USA.
Michael Ibba
The Ohio State University · US

Funding

Mechanisms of translational controlR01GM065183 · NIGMS · OHIO STATE UNIVERSITY · PI DUNHAM, CHRISTINE M, FREDRICK, KURT L · 2003 to 2020
$4.9M
NIGMS NIH HHS GM65183NIGMS NIH HHS R01 GM065183
6 · The paper itself

Abstract

Prokaryotic aminoacylated-transfer RNAs often need to be efficiently segregated between translation and other cellular biosynthetic pathways. Many clinically relevant bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa direct some aminoacylated-tRNA species into peptidoglycan biosynthesis and/or membrane phospholipid modification. Subsequent indirect peptidoglycan cross-linkage or change in membrane permeability is often a prerequisite for high-level antibiotic resistance. In Streptomycetes, aminoacylated-tRNA species are used for antibiotic synthesis as well as antibiotic resistance. The direction of coding aminoacylated-tRNA molecules away from translation and into antibiotic resistance and synthesis pathways are discussed in this review.

Indexed as

Gene Expression Regulation, BacterialAmino AcidsAnti-Bacterial AgentsBacterial ProteinsCell WallDrug Resistance, MicrobialEnterococcus faecalisPeptidoglycanProtein BiosynthesisRNA, Transfer, Amino AcylStaphylococcus aureusStreptococcus pneumoniaeTransfer RNA AminoacylationAmino AcidsAnti-Bacterial AgentsBacterial ProteinsPeptidoglycanRNA, Transfer, Amino AcylAntibioticAntibiotic resistancePathogenesisPeptidoglycanProtein synthesisTranslationtRNA

Identifiers

PMID23907010
PMCPMC3786784
OpenAlexW2055531067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.