ReviewExperimental cell research2013
The role of mechanics in actin stress fiber kinetics.
Review in Experimental cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- An ex vivo culture model of kidney podocyte injury reveals mechanosensitive, synaptopodin-templating, sarcomere-like structures.Science advances · 2022Article
- Mechanics-driven nuclear localization of YAP can be reversed by N-cadherin ligation in mesenchymal stem cells.Nature communications · 2021Article
- Simultaneous Quantification of the Interplay Between Molecular Turnover and Cell Mechanics by AFM-FRAP.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- Regulation of Cell Behavior by Hydrostatic Pressure.Applied mechanics reviews · 2019Review
- Energy dissipation in quasi-linear viscoelastic tissues, cells, and extracellular matrix.Journal of the mechanical behavior of biomedical materials · 2018Article
- Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.Physics of life reviews · 2017Review
- Fibroblasts Slow Conduction Velocity in a Reconstituted Tissue Model of Fibrotic Cardiomyopathy.ACS biomaterials science & engineering · 2017Article
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
- The concentration of stress at the rotator cuff tendon-to-bone attachment site is conserved across species.Journal of the mechanical behavior of biomedical materials · 2016Article
- Nanonet Force Microscopy for Measuring Cell Forces.Biophysical journal · 2016Article
- Remodeling by fibroblasts alters the rate-dependent mechanical properties of collagen.Acta biomaterialia · 2016Article
- An approach to quantifying 3D responses of cells to extreme strain.Scientific reports · 2016Article
- Tissue constructs: platforms for basic research and drug discovery.Interface focus · 2016Article
- Nanoscopic injury with macroscopic consequences: tau proteins as mediators of diffuse axonal injury.Biophysical journal · 2014Article
- Mechanically guided cell migration: less of a stretch than ever.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The dynamic responses of actin stress fibers within a cell's cytoskeleton are central to the development and maintenance of healthy tissues and organs. Disturbances to these underlie a broad range of pathologies. Because of the importance of these responses, extensive experiments have been conducted in vitro to characterize actin cytoskeleton dynamics of cells cultured upon two-dimensional substrata, and the first experiments have been conducted for cells within three-dimensional tissue models. Three mathematical models exist for predicting the dynamic behaviors observed. Surprisingly, despite differing viewpoints on how actin stress fibers are stabilized or destabilized, all of these models are predictive of a broad range of available experimental data. Coarsely, the models of Kaunas and co-workers adopt a strategy whereby mechanical stretch can hasten the depolymerization actin stress fibers that turn over constantly, while the models of Desphande and co-workers adopt a strategy whereby mechanical stress is required to activate the formation of stress fibers and subsequently stabilize them. In three-dimensional culture, elements of both approaches appear necessary to predict observed phenomena, as embodied by the model of Lee et al. After providing a critical review of existing models, we propose lines of experimentation that might be able to test the different principles underlying their kinetic laws.
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Registered trials
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