ArticleMolecular endocrinology (Baltimore, Md.)2013
Cell-autonomous regulation of brown fat identity gene UCP1 by unliganded vitamin D receptor.
Article in Molecular endocrinology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- The Different Shades of Thermogenic Adipose Tissue.Current obesity reports · 2024Review
- Bidirectional effect of vitamin D on brown adipogenesis of C3H10T1/2 fibroblast-like cells.PeerJ · 2023Article
- NFIA determines theiScience · 2022Article
- Adipose-specific VDR Deletion Leads to Hepatic Steatosis in Female Mice Fed a Low-Fat Diet.Endocrinology · 2022Article
- Large-scale transcriptome profiles reveal robust 20-signatures metabolic prediction models and novel role of G6PC in clear cell renal cell carcinoma.Journal of cellular and molecular medicine · 2020Article
- Vitamin D-vitamin D receptor system down-regulates expression of uncoupling proteins in brown adipocyte through interaction with Hairless protein.Bioscience reports · 2020Article
- Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations.BMC medical genetics · 2020Article
- Beyond the bone: Bone morphogenetic protein signaling in adipose tissue.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Review
- Article
- Small molecules for fat combustion: targeting obesity.Acta pharmaceutica Sinica. B · 2019Review
- Brown and Beige Adipose Tissues in Health and Disease.Comprehensive Physiology · 2017Review
- Dissecting the brown adipogenic regulatory network using integrative genomics.Scientific reports · 2017Article
- Adipose-specific Vdr deletion alters body fat and enhances mammary epithelial density.The Journal of steroid biochemistry and molecular biology · 2016Article
- Extraskeletal actions of vitamin D.Annals of the New York Academy of Sciences · 2016Review
- Skin aging: are adipocytes the next target?Aging · 2016Review
- Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3.Endocrinology · 2016Article
- 1,25-Dihydroxyvitamin D3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration.European journal of nutrition · 2015Article
- Vibration Training Triggers Brown Adipocyte Relative Protein Expression in Rat White Adipose Tissue.BioMed research international · 2015Article
- Negative regulators of brown adipose tissue (BAT)-mediated thermogenesis.Journal of cellular physiology · 2014Review
- A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.Endocrinology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
White adipose tissue stores energy in the form of lipids, and brown adipose tissue expends energy via uncoupled fatty acid oxidation, which leads to the generation of heat. Obesity reflects an imbalance between energy storage and energy expenditure and is strongly associated with metabolic and cardiovascular disease. Therefore, there are important medical and biological implications for elucidating the mechanisms that promote energy expenditure in humans. Animal models with altered vitamin D receptor (VDR) expression have changes in energy expenditure. However, the specific mechanism for this effect has not been elucidated and the relevance for humans is unclear. Here we show, using human patient samples from individuals with hereditary vitamin D resistant rickets, that the VDR directly inhibits the expression of uncoupling protein-1 (UCP1), the critical protein for uncoupling fatty acid oxidation in brown fat and burning energy. The inhibition is enforced by VDR occupancy of a negative response element in the promoter proximal region of the UCP1 gene. Deletion of VDR increases UCP1 expression and results in a "browning" of adipocytes. Importantly, we found that this process occurs cell autonomously and is independent of the physiologic VDR hormone ligand, 1,25-dihydroxyvitamin D. These results identify a mechanism for modulating energy balance in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.