ArticleEpilepsia2013
Hypothermia for pediatric refractory status epilepticus.
Article in Epilepsia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.Circulation · 2015Guideline
- Article
- Brain Hypothermia Therapy and Targeted Temperature Management for Acute Encephalopathy in Children: Status and Prospects.Journal of clinical medicine · 2023Review
- Neuroinflammation and status epilepticus: a narrative review unraveling a complex interplay.Frontiers in pediatrics · 2023Review
- Focal Cooling for Drug-Resistant Epilepsy: A Review.JAMA neurology · 2022Review
- Treatment of Super-Refractory Status Epilepticus: A Review.Epilepsy currents · 2021Article
- Extracorporeal Life Support for Cardiac Arrest and Cardiogenic Shock.US cardiology · 2021Review
- Therapeutic hypothermia for pediatric refractory status epilepticus May Ameliorate post-status epilepticus epilepsy.Biomedical journal · 2020Article
- Application of ketogenic diets for pediatric neurocritical care.Biomedical journal · 2020Review
- Clinical application of target temperature management in children with acute encephalopathy-A practical review.Biomedical journal · 2020Review
- Pharmacotherapy for Pediatric Convulsive Status Epilepticus.CNS drugs · 2020Review
- Cannabidiol reduces seizures following CNS infection with Theiler's murine encephalomyelitis virus.Epilepsia open · 2019Article
- Targeted temperature management in the ICU: guidelines from a French expert panel.Annals of intensive care · 2017Review
- A Population Pharmacokinetic Analysis to Study the Effect of Therapeutic Hypothermia on Vancomycin Disposition in Children Resuscitated From Cardiac Arrest.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Article
- Management of Status Epilepticus in Children.Journal of clinical medicine · 2016Review
- Status Epilepticus.Cold Spring Harbor perspectives in medicine · 2016Review
- Early Hypothermia for Refractory Status Epilepticus.Chinese medical journal · 2015Article
- Temperatures achieved in human and canine neocortex during intraoperative passive or active focal cooling.Therapeutic hypothermia and temperature management · 2015Article
- Targeted Temperature Management in Pediatric Central Nervous System Disease.Current treatment options in pediatrics · 2015Article
- Status epilepticus and refractory status epilepticus management.Seminars in pediatric neurology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeRefractory status epilepticus (RSE) is a life-threatening emergency, demonstrating, by definition, significant pharmacoresistance. We describe five cases of pediatric RSE treated with mild hypothermia.
methodsRetrospective chart review was performed of records of children who received hypothermia for RSE at two tertiary-care pediatric hospitals between 2009 and 2012. KEY
findingsFive children with RSE received mild hypothermia (32-35°C). Hypothermia reduced seizure burden during and after treatment in all cases. Prior to initiation of hypothermia, four children (80%) received pentobarbital infusions to treat RSE, but relapsed after pentobarbital discontinuation. No child relapsed after treatment with hypothermia. One child died after redirection of care. Remaining four children were discharged. SIGNIFICANCE: This is the largest pediatric case series reporting treatment of RSE with mild hypothermia. Hypothermia decreased seizure burden during and after pediatric RSE and may prevent RSE relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.