ArticleThe Kaohsiung journal of medical sciences2013
Relationships between changes in leptin and insulin resistance levels in obese individuals following weight loss.
Article in The Kaohsiung journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Effects of Physical Exercise on Adiponectin, Leptin, and Inflammatory Markers in Childhood Obesity: Systematic Review and Meta-Analysis.Childhood obesity (Print)Pooled it
- Comparative evaluation of the therapeutic effect of metformin monotherapy with metformin and acupuncture combined therapy on weight loss and insulin sensitivity in diabetic patients.Nutrition & diabetes · 2016Trial
- Endocrine determinants of changes in insulin sensitivity and insulin secretion during a weight cycle in healthy men.PloS one · 2015Trial
- White adipose tissue expansion as the driver of insulin resistance and secondary endocrine disturbances in obesity- a narrative review.Diabetology & metabolic syndrome · 2026Review
- Diabetes and Risk of Hepatocellular Carcinoma in Cirrhosis Patients with Nonalcoholic Fatty Liver Disease.Gut and liver · 2023Review
- Markers of insulin resistance in Polycystic ovary syndrome women: An update.World journal of diabetes · 2022Review
- Does the weight loss efficacy of alternate day fasting differ according to sex and menopausal status?Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021Article
- Association Between the EAT-Lancet Diet Pattern and Risk of Type 2 Diabetes: A Prospective Cohort Study.Frontiers in nutrition · 2021Article
- Current perspectives of oleic acid: Regulation of molecular pathways in mitochondrial and endothelial functioning against insulin resistance and diabetes.Reviews in endocrine & metabolic disorders · 2020Review
- Review
- The Product of Red Blood Cells and Hematocrit Can Be Used as a Novel Indicator of Impaired Fasting Blood Glucose Status.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet.Aging · 2019Article
- The association of obesity and serum leptin levels with complete blood count and some serum biochemical parameters in Iranian overweight and obese individuals.Medical journal of the Islamic Republic of Iran · 2019Article
- Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers.Respiratory research · 2018Article
- Cigarette Smoking Modulation of Saliva Microbial Composition and Cytokine Levels.International journal of environmental research and public health · 2018Article
- Abdominal obesity and metabolic syndrome: exercise as medicine?BMC sports science, medicine & rehabilitation · 2018Review
- Mechanisms Linking Inflammation to Insulin Resistance.International journal of endocrinology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity can augment insulin resistance (IR), leading to increased risk of diabetes and heart disease. Leptin, ghrelin, and various fatty acids present in the cell membrane may modulate IR. In this study, we aimed to investigate the impact of weight loss on IR, serum leptin/ghrelin levels, and erythrocyte fatty acids, and studied the associations between changes in these variables. A total of 35 obese (body mass index ≥ 27) adults participated in a weight loss program for 3 months. IR was assessed using homeostasis model assessment for insulin resistance (HOMA-IR). The obese participants had a mean weight loss of 5.6 ± 3.8 kg followed by a 16.7% and 23.3% reduction in HOMA-IR and leptin (p < 0.001) levels, and an 11.3% increase in ghrelin levels (p = 0.005). The level of erythrocyte saturates decreased by 2.8%, while the level of n-3 polyunsaturates increased by 16.8% (all p < 0.05). The changes in leptin levels (-5.63 vs. -1.57 ng/mL) were significantly different (p = 0.004) in those with improved IR (changes in HOMA-IR < 0) than those without improvement (changes in HOMA-IR ≥ 0), though there were no differences in the changes of ghrelin (p = 0.120) and erythrocyte fatty acids (all p > 0.05) levels. After adjusting for age, gender, changes in ghrelin, and body fat, we found a significant correlation between decreases in leptin and less risk of no improvement in HOMA-IR levels [odds ratio (OR) = 0.69, p = 0.039]. In conclusion, a moderate weight reduction in obese participants over a short period significantly improved IR. This weight reduction concomitantly decreased serum leptin, increased ghrelin, and elevated some erythrocyte unsaturates. Only leptin correlated independently with IR improvement upon multivariable logistic regression analysis, which indicates that leptin may play a role in the modulation of IR following weight loss.
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