ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2013
Development of food allergies in patients with gastroesophageal reflux disease treated with gastric acid suppressive medications.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.Journal of pediatric gastroenterology and nutrition · 2018Guideline
- Review
- Association of Acid-Suppressive Medication and Antimicrobial Use in Infancy with Food Allergy and Anaphylaxis.Journal of clinical medicine · 2025Article
- Acid-suppressive medication and incidence of chronic childhood immune-mediated diseases: A scoping review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2023Article
- Proton pump inhibitors and the risk of acquiring a penicillin allergy label.Internal medicine journal · 2023Article
- Article
- Pharmacoepidemiology of Drug Exposure in Intubated and Non-Intubated Preterm Infants With Severe Bronchopulmonary Dysplasia.Frontiers in pharmacology · 2021Article
- Preventing Atopic Diseases During Childhood - Early Exposure Matters.Frontiers in immunology · 2021Review
- Selected allergic diseases of the gastrointestinal tract.Przeglad gastroenterologiczny · 2020Review
- Diagnosis and Management of Gastroesophageal Reflux Disease in Infants and Children: from Guidelines to Clinical Practice.Pediatric gastroenterology, hepatology & nutrition · 2019Review
- Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy.Frontiers in immunology · 2019Review
- Review
- Stability of allergens.Molecular immunology · 2018Review
- Environmental factors and eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2018Review
- Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood.JAMA pediatrics · 2018Article
- Experimental Models for Studying Food Allergy.Cellular and molecular gastroenterology and hepatology · 2018Review
- Gastro-Esophageal Reflux in Children.International journal of molecular sciences · 2017Review
- Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy.Nutrients · 2017Review
- Allergic diseases and asthma in pregnancy, a secondary publication.The World Allergy Organization journal · 2017Review
- A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model.Clinical immunology (Orlando, Fla.) · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe prevalence of food allergy has steadily increased, especially in children. Reflux disease, a very common problem in children, is often treated with gastric acid suppressive (GAS) medications which may alter the processing of food allergens, thereby affecting oral mucosal tolerance.
objectiveThe purpose of this study was to determine if use of GAS medications is associated with the occurrence of food allergies in children.
methodsUsing a large national commercial insurance database, we identified 4724 children aged 0-18 yrs who were diagnosed with Gastroesophageal Reflux Disease (GERD) and treated with GAS medications between January 1, 2008 and September 30, 2009. We then matched 4724 children with GERD not treated with GAS medications and 4724 children without GERD and not treated with GAS medications, at a 1:1 ratio, on age, gender and number of atopic risk factors. Patients were followed for 12 months.
resultsIn comparison to the referent (children without GERD who received no GAS medications), children with GERD who were treated with GAS were more likely to be diagnosed with a food allergy (Hazard ratio (HR): 3.67, 95% CI 2.15-6.27), as were children with GERD diagnosis but who were not treated with GAS medications (HR: 2.15, 95% CI: 1.21-3.81). A direct comparison of the two GERD cohorts showed that children with GERD who were treated with GAS had a greater risk of food allergy than those with GERD who were untreated (HR, 1.68, 95%CI, 1.15-2.46).
conclusionTreatment with GAS medications is associated with the occurrence of food allergy, an effect not apparently related to a diagnosis of GERD alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.