ArticleAlcoholism, clinical and experimental research2013
The effects of alcohol on the nonhuman primate brain: a network science approach to neuroimaging.
Article in Alcoholism, clinical and experimental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Anomalies in global network connectivity associated with early recovery from alcohol dependence: A network transcranial magnetic stimulation and electroencephalography study.Addiction biology · 2022Article
- Aberrant prefrontal-parietal-cerebellar circuits in alcohol dependence.Neuropsychiatric disease and treatment · 2018Article
- Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis.Neuropsychiatric disease and treatment · 2017Article
- The effects of chronic alcohol self-administration in nonhuman primate brain networks.Alcoholism, clinical and experimental research · 2015Article
- Graphs of brain networks.Alcoholism, clinical and experimental research · 2013Article
- Altered Forebrain Functional Connectivity and Neurotransmission in a Kinase-Inactive Met Mouse Model of Autism.Molecular imagingArticle
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5 authors.
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Abstract
backgroundAnimal studies have long been an important tool for basic research as they offer a degree of control often lacking in clinical studies. Of particular value is the use of nonhuman primates (NHPs) for neuroimaging studies. Currently, studies have been published using functional magnetic resonance imaging (fMRI) to understand the default-mode network in the NHP brain. Network science provides an alternative approach to neuroimaging allowing for evaluation of whole-brain connectivity. In this study, we used network science to build NHP brain networks from fMRI data to understand the basic functional organization of the NHP brain. We also explored how the brain network is affected following an acute ethanol (EtOH) pharmacological challenge.
methodsBaseline resting-state fMRI was acquired in an adult male rhesus macaque (n = 1) and a cohort of vervet monkeys (n = 10). A follow-up scan was conducted in the rhesus macaque to assess network variability and to assess the effects of an acute EtOH challenge on the brain network.
resultsThe most connected regions in the resting-state networks were similar across species and matched regions identified as the default-mode network in previous NHP fMRI studies. Under an acute EtOH challenge, the functional organization of the brain was significantly impacted.
conclusionsNetwork science offers a great opportunity to understand the brain as a complex system and how pharmacological conditions can affect the system globally. These models are sensitive to changes in the brain and may prove to be a valuable tool in long-term studies on alcohol exposure.
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