Trial reportAmerican journal of respiratory and critical care medicine2013
Body mass index is a stronger predictor than the metabolic syndrome for future asthma in women. The longitudinal CARDIA study.
Trial report in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- The association between body mass index, abdominal fatness, and weight change and the risk of adult asthma: a systematic review and meta-analysis of cohort studies.Scientific reports · 2023Pooled it
- Fueling asthma inflammation via bioenergetic metabolic reprogramming.Redox biology · 2026Article
- Obesity and weight change during eight years in relation to asthma incidence.Scientific reports · 2025Article
- Association of daily steps over time with adult asthma incidence.The Journal of allergy and clinical immunology · 2025Article
- Impact of metabolic and weight components on incident asthma using a real-world cohort.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Prevalence of Obesity and Its Associated Comorbidities in Adults with Asthma: A Single-Center Study in Saudi Arabia.Medicina (Kaunas, Lithuania) · 2024Article
- Chinese expert consensus on the diagnosis, treatment, and management of asthma in women across life.Journal of thoracic disease · 2024Review
- Association of Asthma With Patients Diagnosed With Metabolic Syndrome: A Cohort Study in a Tertiary Care Hospital.Cureus · 2023Article
- The "Asthma-Polycystic Ovary Overlap Syndrome" and the Therapeutic Role of Myo-Inositol.International journal of molecular sciences · 2023Review
- Association between pediatric asthma and adult polycystic ovarian syndrome (PCOS): a cross-sectional analysis of the UAE healthy future Study (UAEHFS).Frontiers in endocrinology · 2023Article
- Associations Between Asthma and Polycystic Ovary Syndrome: Current Perspectives.Frontiers in endocrinology · 2022Review
- Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population.The Korean journal of internal medicine · 2021Article
- Asthma and metabolic syndrome: a comprehensive systematic review and meta-analysis of observational studies.Journal of cardiovascular and thoracic research · 2020Article
- Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Metabolic Dysfunction and Asthma: Current Perspectives.Journal of asthma and allergy · 2020Review
- Sex, obesity, diabetes, and exposure to particulate matter among patients with severe asthma: Scientific insights from a comparative analysis of open clinical data sources during a five-day hackathon.Journal of biomedical informatics · 2019Article
- Diet and Metabolism in the Evolution of Asthma and Obesity.Clinics in chest medicine · 2019Review
- Article
- The relationship between metabolic syndrome and asthma in the elderly.Scientific reports · 2018Article
- Inflammation Gets on the Lung's Nerves: IL-17 and Neuroendocrine Cells Mediate Ozone Responses in Obesity.American journal of respiratory cell and molecular biology · 2018Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
rationaleIt is hypothesized that the metabolic syndrome explains the association between body mass index (BMI) and asthma in adults.
objectivesOur objective was to longitudinally compare the relative strengths of the associations of the metabolic syndrome and BMI with incident asthma in adults.
methodsWe included 4,619 eligible participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort followed over 25 years. Incident asthma was defined by a new self-reported provider asthma diagnosis plus either the presence of asthma symptoms and/or use of asthma medications. Cox proportional hazard analyses were performed. MEASUREMENTS AND MAIN
resultsSix hundred two subjects (417 women and 185 men) developed incident asthma over 25 years of follow-up. Metabolic syndrome predicted incident asthma among women but not men (unadjusted hazard ratios, 1.50 and 0.98; P = 0.01 and 0.93, respectively). BMI had a similar predictive association among women but not men (unadjusted hazard ratios, 1.19 and 1.04 per 5 units of BMI; P < 0.001 and 0.60, respectively). The association of metabolic syndrome with incident asthma in women was no longer statistically significant after adjustment for BMI (P = 0.44). In contrast, the association of BMI with incident asthma in women remained statistically significant after adjusting for the metabolic syndrome (P = 0.01). In a stepwise model, BMI was a stronger predictor than the metabolic syndrome (P = 0.001).
conclusionsBMI is a stronger predictor of incident asthma among women than the metabolic syndrome. Other obesity-associated factors that are not a part of the metabolic syndrome may play a role in the BMI-asthma association in women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.