ArticleJournal of clinical and diagnostic research : JCDR2013
Dental caries vaccine - a possible option?
Article in Journal of clinical and diagnostic research : JCDR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Preclinical evaluation of an mRNA-LNPs vaccine for mucosal protection against dental caries.Frontiers in microbiology · 2026Article
- Comparative Evaluation of Deciduous and Permanent Coronal Caries Using Polarizing Light Microscopy and Scanning Electron Microscopy.TheScientificWorldJournal · 2025Article
- Efficacy of Immunoglobulin Y Chewable Tablets onInternational journal of clinical pediatric dentistry · 2024Article
- In Vitro Synergistic Antibacterial Effects of Extract and Honey Derived from Nigella Sativa on Streptococcus Mutans : Antibacterial Effects of Nigella Sativa Extract and Honey.Galen medical journal · 2024Article
- Bibliometric Analysis of the Current Landscape of Global Scientific Production on the Development of Vaccines against Dental Caries.International journal of dentistry · 2022Article
- Antimicrobial and cytotoxic capacity of pyroligneous extracts films of Eucalyptus grandis and chitosan for oral applications.Scientific reports · 2021Article
- Antibodies generated against dextransucrase exhibit potential anticariostatic properties in Streptococcus mutans.Applied microbiology and biotechnology · 2020Article
- Glycan recognition at the saliva - oral microbiome interface.Cellular immunology · 2018Review
- Taxonomic and Functional Analyses of the Supragingival Microbiome from Caries-Affected and Caries-Free Hosts.Microbial ecology · 2018Article
- Identification of a supramolecular functional architecture of Streptococcus mutans adhesin P1 on the bacterial cell surface.The Journal of biological chemistry · 2015Article
- Binding forces of Streptococcus mutans P1 adhesin.ACS nano · 2015Article
- Nanotechnology in dentistry: prevention, diagnosis, and therapy.International journal of nanomedicine · 2015Review
- Weaker dental enamel explains dental decay.PloS one · 2015Article
- Diagnosis and Prevention Strategies for Dental Caries.Journal of lifestyle medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental caries is an irreversible microbial disease of the calcified tissues of the teeth and it has a multifactorial origin. In India, the dental caries prevalence in 35-44 year olds was reported to be 80-95% in a DCI survey. Among the elderly in the 65-74 years age group, the DCI survey reported the caries prevalence to be about 70%, while the present survey reported it to be 51- 95% in various states. Surveys which were done on school children in India showed a carie prevalence of approximately 58%.Among the U.S. population, a survey showed an incidence of 93.8% in adults with either past or present coronal caries and an incidence of 45.3% in children 23. In countries like Brazil and China, it is reaching epidemic proportions. Thus, more effective public-health measures are needed to combat dental caries. Mutans streptococci is one of the main microorganisms which are associated with the aetiology of dental caries. Preclinical studies of immunological interventions have shown that the disease can be interrupted. Clinical trials have indicated that a mucosal immune response to Streptococcus mutans crucial antigens can influence the pathogenesis of dental caries. The dental caries vaccine, when it is used in appropriate individuals at the appropriate time, can reduce the reemergence of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.