ArticleJournal of clinical and diagnostic research : JCDR2013
Adverse drug reaction monitoring of antidepressants in the psychiatry outpatients department of a tertiary care teaching hospital.
Article in Journal of clinical and diagnostic research : JCDR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Pharmacogenetics testing for poor response to antidepressants: a transnosographic case series.Frontiers in pharmacology · 2024Article
- Cost-effectiveness of pharmacogenomic-guided treatment for major depression.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- Research on treatment-related aspects of depression from India in the preceding decade (2014-2023): An updated systematic review.Indian journal of psychiatry · 2023Review
- Pharmacogenetic Guidelines for Psychotropic Drugs: Optimizing Prescriptions in Clinical Practice.Pharmaceutics · 2023Review
- Self-Reported Antidepressant Drug Side Effects, Medication Adherence, and Its Associated Factors among Patients Diagnosed with Depression at the Psychiatric Hospital of Nepal.Depression research and treatment · 2020Article
- Trends in hospital admissions due to antidepressant-related adverse drug events from 2001 to 2011 in the U.S.BMC health services research · 2017Article
- Monitoring of adverse drug reactions in psychiatry outpatient department of a Secondary Care Hospital of Ras Al Khaimah, UAE.Journal of basic and clinical pharmacy · 2016Article
- A prospective observational study to evaluate safety reporting of antidepressants at a tertiary care hospital in India.Indian journal of pharmacologyObservational
- Assessment of incidence, causality, severity, and preventability of suspected adverse drug reactions to antidepressant medications in a psychiatry outpatient setting of a secondary care hospital.Journal of pharmacy & bioallied sciencesArticle
- An observational study to evaluate the awareness of drug treatment, prescription pattern, adverse drug reactions, and adherence in patients of major depressive disorder.Perspectives in clinical researchArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
introductionDepression is a prevalent mental disorder and the 4(th) leading cause of disability in the world as per the World Health Organization (WHO). The adverse Drug Reactions (ADRs) to antidepressants are common and they can lead to a non compliance or even a discontinuation of the therapy. This study entitled us to monitor the ADR profile of the antidepressants in a tertiary care teaching hospital. PATIENTS AND
methodsA longitudinal, observational study was conducted in the Outpatients Department of Psychiatry in S.C.B. Medical College and Hospital l in collaboration with the I.M.S and SUM Hospital. A total of 160 cases were studied for ADRs by using a predesigned CDSCO form. The patients who were on TCAs, SSRIs and newer antidepressants (SNRIs/NDRIs) were assessed by doing physical examinations, neurological examinations and relevant lab tests. The causalities were assessed by the criteria of the WHO-UMC. The analysis of ADRs was done by using the Chi square test.
resultsAmong the 160 patients who took antidepressants, 26.87% reported ADRs, with at least one possible causality.None were labeled as certain, as a rechallenge was not performed.ADRs were mostly observed in polytherapy (14.37%) and with antidepressants like TCAs (58.84%).
conclusionsAgitation, anxiety and insomnia were the common ADRs which were associated with the use of antidepressants. This study offers a representative profile of the ADRs which can be expected in the Psychiatry Outpatients Department and due care must be taken to avoid these ADRs.
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