ArticleAsian Pacific journal of tropical biomedicine2013
Statistical optimization and anticancer activity of a red pigment isolated from Streptomyces sp. PM4.
Article in Asian Pacific journal of tropical biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 23 citations in OpenAlex.
- Unlocking the microbial treasure trove: advances in Streptomyces derived secondary metabolites in the battle against cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Co-cultivation ofFrontiers in microbiology · 2019Article
- Profiling of red pigment produced by3 Biotech · 2018Article
- Optimization of the Cytotoxic Activity of ThreeBioMed research international · 2018Article
- Enhanced candicidal compound production by a new soil isolate Penicillium verruculosum MKH7 under submerged fermentation.BMC microbiology · 2016Article
- Terpenoid bioactive compound from Streptomyces rochei (M32): taxonomy, fermentation and biological activities.World journal of microbiology & biotechnology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo enhance the pigment production by Streptomyces sp. PM4 for evaluating its anticancer activity.
methodsResponse surface methodology was employed to enhance the production of red pigment from Streptomyces sp. PM4. Optimized pigment was purified and evaluated for the anticancer activity against HT1080, Hep2, HeLa and MCF7 cell lines by MTT assay.
resultsBased on the response surface methodology, it could be concluded that maltose (4.06 g), peptone (7.34 g), yeast extract (4.34 g) and tyrosine (2.89 g) were required for the maximum production of pigment (1.68 g/L) by the Streptomyces sp. PM4. Optimization of the medium with the above tested features increased the pigment yield by 4.6 fold. Pigment showed the potential anticancer activity against HT1080, HEp-2, HeLa and MCF-7 cell lines with the IC50 value of 18.5, 15.3, 9.6 and 8.5 respectively.
conclusionsThe study revealed that the maximum amount of pigment could be produced to treat cancer.
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