ArticleAsian Pacific journal of tropical biomedicine2013
Down-regulation of tyrosinase, TRP-1, TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma.
Article in Asian Pacific journal of tropical biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
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- Bioactive Lipid Mediator Resolvin D5 Suppresses Melanogenesis in α-MSH-Stimulated B16F10 Cells via ROS-Associated p38/β-Catenin/MITF Regulation.Journal of microbiology and biotechnology · 2026Article
- Jatropholone B from Jatropha curcas inhibits melanin synthesisextracellular signal-regulated kinase activation in Mel-Ab cell.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Promoting the Emerging Role of Pulse By-Products as Valuable Sources of Functional Compounds and Novel Food Ingredients.Foods (Basel, Switzerland) · 2025Review
- Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells.Toxicological research · 2025Article
- Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression.Biomolecules & therapeutics · 2024Article
- Hesperidin from Orange Peel as a Promising Skincare Bioactive: An Overview.International journal of molecular sciences · 2024Review
- Ethyl Acetate Fraction from aInternational journal of molecular sciences · 2023Article
- Anti-Melanogenic Effects ofPlants (Basel, Switzerland) · 2023Article
- Inhibition of Melanogenesis by Essential Oils from the Citrus Cultivars Peels.International journal of molecular sciences · 2023Article
- Protective Effect of the Hydrophilic Extract ofAntioxidants (Basel, Switzerland) · 2022Article
- Chemical Constituents, Antioxidant, Anti-Tyrosinase, Cytotoxicity, and Anti-Melanogenesis Activities ofMolecules (Basel, Switzerland) · 2022Article
- Identification of a Novel Class of Anti-Melanogenic Compounds, (Antioxidants (Basel, Switzerland) · 2022Article
- α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway.Biochemistry and biophysics reports · 2021Article
- Additive Effect of a Combination ofPharmaceuticals (Basel, Switzerland) · 2020Article
- Induction of Melanogenesis by Fosfomycin in B16F10 Cells Through the Upregulation of P-JNK and P-p38 Signaling Pathways.Antibiotics (Basel, Switzerland) · 2020Article
- Benefits of Hesperidin for Cutaneous Functions.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Antimelanogenesis and skin-protective activities ofJournal of ginseng research · 2018Article
- Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model.Journal of natural medicines · 2018Article
- Soyasaponin Ag inhibits α‑MSH‑induced melanogenesis in B16F10 melanoma cells via the downregulation of TRP‑2.International journal of molecular medicine · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the suitability of citrus-press cakes, by-products of the juice industry as a source for the whitening agents for cosmetic industry.
methodsEthylacetate extracts of citrus-press cakes (CCE) were examined for their anti-melanogenic potentials in terms of the inhibition of melanin production and mechanisim of melanogenesis by using Western Blot analysis with tyrosinese, tyrosinase-related protein-1 (TRP-1), TRP2, and microphthalmia-associated transcription factor (MITF) proteins. To apply the topical agents, citrus-press cakes was investigated the safety in human skin cell line. Finally flavonoid analysis of CCE was also determined by HPLC analysis.
resultsResults indicated that CCE were shown to down-regulate melanin content in a dose-dependent pattern. The CCE inhibited tyrosinase, TRP-2, and MITF expressions in a dose-dependent manner. To test the applicability of CCE to human skin, we used MTT assay to assess the cytotoxic effects of CCE on human keratinocyte HaCaT cells. The CCE exhibited low cytotoxicity at 50 µg/mL. Characterization of the citrus-press cakes for flavonoid contents using HPLC showed varied quantity of rutin, narirutin, and hesperidin.
conclusionsConsidering the anti-melanogenic activity and human safety, CCE is considered as a potential anti-melanogenic agent and may be effective for topical application for treating hyperpigmentation disorders.
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