Trial reportSleep2013
Randomized controlled trial of noninvasive positive pressure ventilation (NPPV) versus servoventilation in patients with CPAP-induced central sleep apnea (complex sleep apnea).
Trial report in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-invasive positive pressure ventilation for central sleep apnoea in adults.The Cochrane database of systematic reviews · 2022Pooled it
- A novel adaptive servoventilation (ASVAuto) for the treatment of central sleep apnea associated with chronic use of opioids.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Trial
- Trial
- Holistic integrative analysis of circulatory parameters: effects of CPAP titration in patients with obstructive sleep apnea.Journal of thoracic disease · 2025Article
- Insights, recommendations, and research priorities for central sleep apnea: report from an expert panel.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Central sleep apnoea: not just one phenotype.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Adaptive servo-ventilation and mortality in patients with systolic heart failure and central sleep apnea: a single-center experience.Sleep & breathing = Schlaf & Atmung · 2023Article
- Sleep and Breathing Conference highlights 2023: a summary by ERS Assembly 4.Breathe (Sheffield, England) · 2023Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Review
- Sleep-Related Breathing Disorders: When CPAP Is Not Enough.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Nocturnal supports for patients with central sleep apnea and heart failure: a systemic review and network meta-analysis of randomized controlled trials.Annals of translational medicine · 2019Article
- Adaptive servoventilation in clinical practice: beyond SERVE-HF?ERJ open research · 2017Article
- Clinical predictors of central sleep apnea evoked by positive airway pressure titration.Nature and science of sleep · 2016Article
- Complex sleep apnea syndrome.Sleep disorders · 2014Review
- Innovative treatments for adults with obstructive sleep apnea.Nature and science of sleep · 2014Review
- Noninvasive ventilation in acute respiratory failure.International journal of chronic obstructive pulmonary disease · 2014Review
- Article
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo compare the treatment effect of noninvasive positive pressure ventilation (NPPV) and anticyclic servoventilation in patients with continuous positive airway pressure (CPAP)-induced central sleep apnea (complex sleep apnea).
designRandomized controlled trial.
settingSleep center. PATIENTS: Thirty patients who developed complex sleep apnea syndrome (CompSAS) during CPAP treatment.
interventionsNPPV or servoventilation. MEASUREMENTS AND
resultsPatients were randomized to NPPV or servo-ventilation. Full polysomnography (PSG) was performed after 6 weeks. On CPAP prior to randomization, patients in the NPPV and servoventilator arm had comparable apnea-hypopnea indices (AHI, 28.6 ± 6.5 versus 27.7 ± 9.7 events/h (mean ± standard deviation [SD])), apnea indices (AI,19 ± 5.6 versus 21.1 ± 8.6 events/h), central apnea indices (CAI, 16.7 ± 5.4 versus 18.2 ± 7.1 events/h), oxygen desaturation indices (ODI,17.5 ± 13.1 versus 24.3 ± 11.9 events/h). During initial titration NPPV and servoventilation significantly improved the AHI (9.1 ± 4.3 versus 9 ± 6.4 events/h), AI (2 ± 3.1 versus 3.5 ± 4.5 events/h) CAI (2 ± 3.1 versus 2.5 ± 3.9 events/h) and ODI (10.1 ± 4.5 versus 8.9 ± 8.4 events/h) when compared to CPAP treatment (all P < 0.05). After 6 weeks we observed the following differences: AHI (16.5 ± 8 versus 7.4 ± 4.2 events/h, P = 0.027), AI (10.4 ± 5.9 versus 1.7 ± 1.9 events/h, P = 0.001), CAI (10.2 ± 5.1 versus 1.5 ± 1.7 events/h, P < 0.0001)) and ODI (21.1 ± 9.2 versus 4.8 ± 3.4 events/h, P < 0.0001) for NPPV and servoventilation, respectively. Other sleep parameters were unaffected by any form of treatment.
conclusionsAfter 6 weeks, servoventilation treated respiratory events more effectively than NPPV in patients with complex sleep apnea syndrome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.