ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Transcranial direct current stimulation (tDCS) paired with massed practice training to promote adaptive plasticity and motor recovery in chronic incomplete tetraplegia: A pilot study.The journal of spinal cord medicine · 2018Trial
- Restoring initial steps by intermittent theta burst stimulation in complete spinal cord injury patient: a case report.Spinal cord series and cases · 2024Article
- Motor Pathways Reorganization following Surgical Decompression for Degenerative Cervical Myelopathy: A Combined Navigated Transcranial Magnetic Stimulation and Clinical Outcome Study.Brain sciences · 2024Article
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- Utility of transcranial magnetic stimulation in the assessment of spinal cord injury: Current status and future directions.Frontiers in rehabilitation sciences · 2022Review
- Paired pulse transcranial magnetic stimulation in the assessment of biceps voluntary activation in individuals with tetraplegia.Frontiers in human neuroscience · 2022Article
- Abnormal changes in motor cortical maps in humans with spinal cord injury.The Journal of physiology · 2021Article
- Duration and reliability of the silent period in individuals with spinal cord injury.Spinal cord · 2021Article
- Changes in motoneuron excitability during voluntary muscle activity in humans with spinal cord injury.Journal of neurophysiology · 2020Article
- Imbalanced Corticospinal and Reticulospinal Contributions to Spasticity in Humans with Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Operant conditioning of the tibialis anterior motor evoked potential in people with and without chronic incomplete spinal cord injury.Journal of neurophysiology · 2018Article
- Catgut implantation at acupoints increases the expression of glutamate aspartate transporter and glial glutamate transporter-1 in the brain of rats with spasticity after stroke.Neural regeneration research · 2018Article
- Antispasmodic medications may be associated with reduced recovery during inpatient rehabilitation after traumatic spinal cord injury.The journal of spinal cord medicine · 2018Article
- Afferent input and sensory function after human spinal cord injury.Journal of neurophysiology · 2018Review
- A novel cortical target to enhance hand motor output in humans with spinal cord injury.Brain : a journal of neurology · 2017Article
- Altered corticospinal function during movement preparation in humans with spinal cord injury.The Journal of physiology · 2017Article
- Reliability of TMS metrics in patients with chronic incomplete spinal cord injury.Spinal cord · 2016Article
- Impaired Organization of Paired-Pulse TMS-Induced I-Waves After Human Spinal Cord Injury.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Challenges in Recruitment for the Study of Noninvasive Brain Stimulation in Stroke: Lessons from Deep Brain Stimulation.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2016Article
- Effects of repetitive transcranial magnetic stimulation on recovery of function after spinal cord injury.Archives of physical medicine and rehabilitation · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Baclofen is a GABAB receptor agonist commonly used to relief spasticity related to motor disorders. The effects of baclofen on voluntary motor output are limited and not yet understood. Using noninvasive transcranial magnetic and electrical stimulation techniques, we examined electrophysiological measures probably involving GABAB (long-interval intracortical inhibition and the cortical silent period) and GABAA (short-interval intracortical inhibition) receptors, which are inhibitory effects mediated by subcortical and cortical mechanisms. We demonstrate increased active long-interval intracortical inhibition and prolonged cortical silent period during voluntary activity of an intrinsic finger muscle in humans with chronic incomplete cervical spinal cord injury (SCI) compared with age-matched controls, whereas resting long-interval intracortical inhibition was unchanged. However, long-term (~6 years) use of baclofen decreased active long-interval intracortical inhibition to similar levels as controls but did not affect the duration of the cortical silent period. We found a correlation between signs of spasticity and long-interval intracortical inhibition in patients with SCI. Short-interval intracortical inhibition was decreased during voluntary contraction compared with rest but there was no effect of SCI or baclofen use. Together, these results demonstrate that baclofen selectively maintains use-dependent modulation of largely subcortical but not cortical GABAB neuronal pathways after human SCI. Thus, cortical GABA(B) circuits may be less sensitive to baclofen than spinal GABAB circuits. This may contribute to the limited effects of baclofen on voluntary motor output in subjects with motor disorders affected by spasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.