ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Cognitive outcomes of deep brain stimulation depend on age and hippocampal connectivity in Parkinson's and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- mGluR-dependent plasticity in rodent models of Alzheimer's disease.Frontiers in synaptic neuroscience · 2023Article
- Impairment of synaptic plasticity and novel object recognition in the hypergravity-exposed rats.Scientific reports · 2020Article
- Hypergravity induced disruption of cerebellar motor coordination.Scientific reports · 2020Article
- Reduced cognitive performance in aged rats correlates with increased excitation/inhibition ratio in the dentate gyrus in response to lateral entorhinal input.Neurobiology of aging · 2019Article
- Hippocampal Homer1b/c is necessary for contextual fear conditioning and group I metabotropic glutamate receptor mediated long-term depression.Neurobiology of learning and memory · 2018Article
- Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats.Neurobiology of aging · 2018Article
- Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease.Seminars in cell & developmental biology · 2018Review
- Long term potentiation, but not depression, in interlamellar hippocampus CA1.Scientific reports · 2018Article
- Brief Novel Visual Experience Fundamentally Changes Synaptic Plasticity in the Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Heightened cortical excitability in aged rodents with memory impairment.Neurobiology of aging · 2017Article
- Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neurocognitive Aging and the Hippocampus across Species.Trends in neurosciences · 2015Review
- Using the spatial learning index to evaluate performance on the water maze.Behavioral neuroscience · 2015Review
- mGlu5 acts as a switch for opposing forms of synaptic plasticity at mossy fiber-CA3 and commissural associational-CA3 synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Interlamellar CA1 network in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Glutamatergic signaling and low prodynorphin expression are associated with intact memory and reduced anxiety in rat models of healthy aging.Frontiers in aging neuroscience · 2014Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The impact of aging on cognitive capabilities varies among individuals ranging from significant impairment to preservation of function on par with younger adults. Research on the neural basis for age-related memory decline has focused primarily on the CA1 region of the hippocampus. However, recent studies in elderly human and rodents indicate that individual differences in cognitive aging are more strongly tied to functional alterations in CA3 circuits. To examine synaptic plasticity in the CA3 region, we used aged rats behaviorally characterized in a hippocampal-dependent task to evaluate the status of long-term potentiation and long-term depression (LTP and LTD) in the associative/commissural pathway (A/C → CA3), which provides the majority of excitatory input to CA3 pyramidal neurons. We found that, unlike in CA1 synapses, in A/C → CA3 LTP is minimally affected by age. However, two forms of LTD, involving NMDA and metabotropic glutamate receptors (mGluR), are both greatly reduced in age-impaired rats. Age-unimpaired rats, in contrast, had intact mGluR LTD. These findings indicate that the integrity of mGluR-LTD at A/C → CA3 inputs may play a crucial role in maintaining the performance of CA3 circuitry in aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.