ArticleJournal of neurointerventional surgery2014
Human placenta as an ex vivo vascular model for neurointerventional research.
Article in Journal of neurointerventional surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The role of simulation in neurosurgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Pooled it
- Human placenta as a biological vascular model for endovascular training.Frontiers in neurology · 2026Article
- The Impact of Glycaemic Variability on Vascular Dysfunction in Diabetes.Biomolecules · 2025Review
- The modified placenta model for microsurgery training: Recommended methods for comprehensive microsurgery experience.Journal of hand and microsurgery · 2024Article
- Current Approaches and Methods to Understand Acute Ischemic Stroke Treatment Using Aspiration Thrombectomy.Cardiovascular engineering and technology · 2024Review
- tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments.Science advances · 2024Article
- Direct Aspiration versus Combined Technique for Distal Medium-Vessel Occlusions: Comparison on a Human Placenta Model.AJNR. American journal of neuroradiology · 2023Article
- Modern Brain Arteriovenous Malformation Models: A Review.Stroke (Hoboken, N.J.) · 2022Review
- A Review of the Advancements in theFrontiers in medical technology · 2022Review
- The human placenta as a model for training and research in mechanical thrombectomy: Clarifications and use of the chorionic plate veins.Frontiers in neurology · 2022Article
- Dose-Response Relationship and Threshold Drug Dosage Identification for a Novel Hybrid Mechanical-Thrombolytic System with an Ultra-Low Dose Patch.Cellular and molecular bioengineering · 2021Article
- John Ching-Kwong Kwok (1951-2020): The Renaissance Man of Hong Kong Neurosurgery.Asian journal of neurosurgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman placenta is a convenient resource for biomedical research, and has not yet been used for neurointerventional surgery research.
objectiveOur objective was to explore the feasibility of using human placenta to test various endovascular interventions and for training.
design18 placentas soon after delivery were prepared for six pilot studies. (1) Study on anatomical similarity to human cerebral vessel. (2) Simulation of stent assisted coiling and flow diversion on an aneurysm model. (3) Simulation of intra-arterial thrombolysis. (4) Simulation of embolization of arteriovenous malformation with glues. (5) Simulation of mechanical thrombolysis and comparison of different devices. (6) Vascular model for training of neurointerventionalists.
resultsWhen the chorionic plate vessels were compared with the cerebral cortical vessels, similarities were found in vascular branch patterns, histological cross sections, and angiographic appearances. Due to the semitransparency of its vessel wall, performance of flow diverter and stent assisted coiling of an aneurysm could be visualized under direct microscopic observation. Similarly, timing of clot lysis and glue polymerization could be estimated. Endothelial change after thrombectomy could be assessed by histological methods. From these pilot studies, the placenta model could be adopted to simulate various clinical situations. It is also ideal for interventional radiology training.
conclusionsIt is feasible to adopt the human placenta as an ex vivo vascular model in neurointerventional surgery research due to the fact that its vessels resemble the brain vasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.