ArticleThe Journal of infectious diseases2013
Associations between maternal helminth and malaria infections in pregnancy and clinical malaria in the offspring: a birth cohort in entebbe, Uganda.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Over-dispersion in malaria-schistosoma co-infection: insights from a meta-analytical approach and systematic review.Infectious diseases of poverty · 2026Pooled it
- Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Comorbidity of Geo-Helminthes among Malaria Outpatients of the Health Facilities in Ethiopia: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Impact of Malaria in Pregnancy on Risk of Malaria in Young Children: Systematic Review and Meta-Analyses.The Journal of infectious diseases · 2020Pooled it
- Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review.Malaria journal · 2019Pooled it
- Cohort profile: the Entebbe Mother and Baby Study (EMaBS).BMJ open · 2026Trial
- Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.PLoS medicine · 2018Trial
- Placental but Not Peripheral Plasmodium falciparum Infection During Pregnancy Is Associated With Increased Risk of Malaria in Infancy.The Journal of infectious diseases · 2017Trial
- The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial.PLoS neglected tropical diseases · 2017Trial
- The impact of soil transmitted helminth on malaria clinical presentation and treatment outcome: A case control study among children in Bagamoyo district, coastal region of Tanzania.PLoS neglected tropical diseases · 2024Article
- Article
- Blood pressure risk factors in early adolescents: results from a Ugandan birth cohort.Journal of human hypertension · 2019Observational
- Hookworm infection is associated with decreased CD4+ T cell counts in HIV-infected adult Ugandans.PLoS neglected tropical diseases · 2017Article
- Epidemiology of Mansonella perstans in the middle belt of Ghana.Parasites & vectors · 2017Article
- Molecular Epidemiology of Blood-Borne Human Parasites in a Loa loa-, Mansonella perstans-, and Plasmodium falciparum-Endemic Region of Cameroon.The American journal of tropical medicine and hygiene · 2016Article
- Helminth infection during pregnancy: insights from evolutionary ecology.International journal of women's health · 2016Review
- RETRACTED: Mansonella, including a Potential New Species, as Common Parasites in Children in Gabon.PLoS neglected tropical diseases · 2015Article
- Pregnancy and helminth infections.Parasite immunology · 2014Review
- Are pregnant women with chronic helminth infections more susceptible to congenital infections?Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundHelminth and malaria coinfections are common in the tropics. We investigated the hypothesis that prenatal exposure to these parasites might influence susceptibility to malaria in childhood.
methodsIn a birth cohort of 2345 mother-child pairs in Uganda, maternal helminth and malaria infection status was determined during pregnancy, and childhood malaria episodes were recorded from birth to age 5 years. We examined associations between maternal infections and malaria in the offspring.
resultsCommon maternal infections were hookworm (45%), Mansonella perstans (21%), Schistosoma mansoni (18%), and Plasmodium falciparum (11%). At age 5 years, 69% of the children were still under follow-up. The incidence of malaria was 34 episodes per 100 child-years, and the mean prevalence of asymptomatic malaria at annual visits was 5.4%. Maternal hookworm and M. perstans infections were associated with an increased rate of childhood clinical malaria (adjusted hazard ratio [aHR], 1.24, 95% confidence interval [CI], 1.10-1.41; aHR, 1.20, 95% CI, 1.05-1.38, respectively). S. mansoni infection had no consistent association with childhood malaria.
conclusionsThis is the first report of an association between helminth infections in pregnancy and malaria in the offspring and indicates that helminth infections in pregnancy may increase the burden of childhood malaria morbidity.
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