SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013
Association between tumor necrosis factor β 252 A/G polymorphism and risk of gastric cancer: a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quantitative assessment of the associations between DNA repair gene XRCC3 Thr241Met polymorphism and gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Polymorphisms of the LTA gene may contribute to the risk of myocardial infarction: a meta-analysis.PloS one · 2014Pooled it
- A phase IIa study of rhLTα-Da in combination with cisplatin and fluorouracil for patients with metastatic esophageal squamous cell carcinoma or gastric adenocarcinoma.Medical oncology (Northwood, London, England) · 2016Trial
- Associations of lymphotoxin-a (LTA) rs909253 A/G gene polymorphism, plasma level and risk of ankylosing spondylitis in a Chinese Han population.Scientific reports · 2020Article
- Article
- Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike.World journal of gastrointestinal oncology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factor β (TNF-β) 252 A/G polymorphism has been implicated to be associated with risk of gastric cancer, but previous studies showed inconsistent and inconclusive results. Therefore, we performed a meta-analysis to assess the association between TNF-β 252 A/G polymorphism and gastric cancer risk. Relevant studies were searched from PubMed database. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of the associations between TNF-β 252 A/G polymorphism and gastric cancer risk. Overall, 11 individual case-control studies with 2,270 cases and 4,404 controls were included in the final meta-analysis. Meta-analysis of total 11 studies showed that TNF-β 252 A/G polymorphism was associated with the risk of gastric cancer (G vs. A: OR = 1.10, 95% CI 1.02-1.19, P = 0.015; GG/AG vs. AA: OR = 1.21, 95% CI 1.00-1.47, P = 0.049). Subgroup analysis by ethnicity showed that TNF-β 252 A/G polymorphism was only associated with the risk of gastric cancer in Asians, but not Caucasians. The findings from the current meta-analysis suggest that TNF-β 252 A/G polymorphism is associated with the risk of gastric cancer, especially in Asians.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.