Trial reportIndian journal of pediatrics2014
Adding hydrocortisone as 1st line of inotropic treatment for hypotension in very low birth weight infants.
Trial report in Indian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Timing of hydrocortisone therapy in neonates with shock: a systematic review, meta-analysis, and clinical practice guideline.Frontiers in pediatrics · 2025Pooled it
- Systemic corticosteroids for the prevention of bronchopulmonary dysplasia, a network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Late (≥ 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Early (< 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Eligibility Criteria and Representativeness of Randomized Clinical Trials That Include Infants Born Extremely Premature: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- Assessment of Postnatal Corticosteroids for the Prevention of Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Network Meta-analysis.JAMA pediatrics · 2021Pooled it
- Efficacy and safety of systemic hydrocortisone for the prevention of bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.European journal of pediatrics · 2019Pooled it
- Early (< 8 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Early hydrocortisone verses placebo in neonatal shock- a double blind Randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Use of hydrocortisone in extremely preterm infants: emphasis on those born least mature.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews.The Cochrane database of systematic reviews · 2024Review
- Management of mad honey intoxication with suspected anaphylaxis in Nepal: a case report.Annals of medicine and surgery (2012) · 2023Article
- Drug versus placebo randomized controlled trials in neonates: A review of ClinicalTrials.gov registry.PloS one · 2017Article
- Adding hydrocortisone as 1st line of inotropic treatment for hypotension in very low birth weight infants: correspondence.Indian journal of pediatrics · 2014Article
- Adding hydrocortisone as 1st line of inotropic treatment for hypotension in very low birth weight infants: authors' reply.Indian journal of pediatrics · 2014Article
- Systematic Review and Meta-Analysis of Cardiovascular Medications in Neonatal Hypotension.Biomedicine hubArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this pilot study the authors demonstrate the feasibility, effectiveness and safety of the combined early treatment with hydrocortisone and dopamine for refractory hypotension in preterm newborns. Very low birth weight infants born at gestational age < 30 wk or birth weight < 1250 g in the first 48 h of life with hypotension after receiving 10-20 mL/kg bolus of normal saline, were randomized to receive concurrently with the initiation of dopamine, intravenous hydrocortisone (11 infants) or an equivalent volume of placebo (11 infants). Despite no significant clinical difference between the groups including gestational age, birth weight, prevalence of chorioamnionitis, prenatal steroid treatment, cord PH, baseline cortisol level, there was a trend towards lower incidence of bronchopulmonary dysplasia (BPD), and higher survival without BPD rate in the hydrocortisone group. In this very sick small group of infants, hydrocortisone was not associated with more adverse effects, but rather showed a trend toward association with better outcome, including survival without BPD.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.