ArticleEpidemiology (Cambridge, Mass.)2013
Prenatal methylmercury exposure and genetic predisposition to cognitive deficit at age 8 years.
Article in Epidemiology (Cambridge, Mass.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sex difference of pre- and post-natal exposure to six developmental neurotoxicants on intellectual abilities: a systematic review and meta-analysis of human studies.Environmental health : a global access science source · 2023Pooled it
- Mercury Exposure and Heart Rate Variability: a Systematic Review.Current environmental health reports · 2015Pooled it
- Neurobehavioural effects of developmental toxicity.The Lancet. Neurology · 2014Pooled it
- Lack of beneficiary effect of levothyroxine therapy of pregnant women with subclinical hypothyroidism in terms of neurodevelopment of their offspring.Archives of gynecology and obstetrics · 2024Trial
- Prenatal and childhood exposures to heavy metals and their associations with child cognition, motor skills, behaviour and mental health.Essays in biochemistry · 2025Review
- Article
- Global Human Threat: The Potential Synergism between Mercury Intoxication and COVID-19.International journal of environmental research and public health · 2023Article
- Evidence on Neurotoxicity after Intrauterine and Childhood Exposure to Organomercurials.International journal of environmental research and public health · 2023Review
- Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs.Frontiers in toxicology · 2023Review
- Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a Colombian population.Scientific reports · 2021Article
- A Birth Cohort Study on the Genetic Modification of the Association of Prenatal Methylmercury With Child Cognitive Development.American journal of epidemiology · 2019Article
- Analysis of Nonlinear Associations between Prenatal Methylmercury Exposure from Fish Consumption and Neurodevelopmental Outcomes in the Seychelles Main Cohort at 17 Years.Stochastic environmental research and risk assessment : research journal · 2018Article
- Maternal prenatal blood mercury is not adversely associated with offspring IQ at 8 years provided the mother eats fish: A British prebirth cohort study.International journal of hygiene and environmental health · 2017Article
- Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood.Scientific reports · 2017Article
- Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview.International journal of environmental research and public health · 2017Review
- Biomarkers of mercury toxicity: Past, present, and future trends.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Prenatal mercury exposure and offspring behaviour in childhood and adolescence.Neurotoxicology · 2016Article
- Paracelsus Revisited: The Dose Concept in a Complex World.Basic & clinical pharmacology & toxicology · 2016Review
- Effect of Gene-Mercury Interactions on Mercury Toxicokinetics and Neurotoxicity.Current environmental health reports · 2015Review
- Multifactorial Origin of Neurodevelopmental Disorders: Approaches to Understanding Complex Etiologies.Toxics · 2015Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundCognitive consequences at school age associated with prenatal methylmercury (MeHg) exposure may need to take into account nutritional and sociodemographic cofactors as well as relevant genetic polymorphisms.
methodsA subsample (n = 1,311) of the Avon Longitudinal Study of Parents and Children (Bristol, UK) was selected, and mercury (Hg) concentrations were measured in freeze-dried umbilical cord tissue as a measure of MeHg exposure. A total of 1135 children had available data on 247 single-nucleotide polymorphisms (SNPs) within relevant genes, as well as the Wechsler Intelligence Scale for Children Intelligence Quotient (IQ) scores at age 8 years. Multivariate regression models were used to assess the associations between MeHg exposure and IQ and to determine possible gene-environment interactions.
resultsHg concentrations indicated low background exposures (mean = 26 ng/g, standard deviation = 13). Log10-transformed Hg was positively associated with IQ, which attenuated after adjustment for nutritional and sociodemographic cofactors. In stratified analyses, a reverse association was found in higher social class families (for performance IQ, P value for interaction = 0.0013) among whom there was a wider range of MeHg exposure. Among 40 SNPs showing nominally significant main effects, MeHg interactions were detected for rs662 (paraoxonase 1) and rs1042838 (progesterone receptor) (P < 0.05) and for rs3811647 (transferrin) and rs2049046 (brain-derived neurotrophic factor) (P < 0.10).
conclusionsIn this population with a low level of MeHg exposure, there were only equivocal associations between MeHg exposure and adverse neuropsychological outcomes. Heterogeneities in several relevant genes suggest possible genetic predisposition to MeHg neurotoxicity in a substantial proportion of the population. Future studies need to address this possibility.
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