ArticleGenes and immunity2013
Genetic burden in multiple sclerosis families.
Article in Genes and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis.International journal of epidemiology · 2016Pooled it
- Multiple Sclerosis Polygenic Risk Is Not Enriched in Three Multicase Families in Comparison to Population-Based Cases.Human mutation · 2024Article
- Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.Brain : a journal of neurology · 2023Article
- The gut microbiome molecular mimicry piece in the multiple sclerosis puzzle.Frontiers in immunology · 2022Review
- Liver kinase B1 rs9282860 polymorphism and risk for multiple sclerosis in White and Black Americans.Multiple sclerosis and related disorders · 2021Article
- Genetic susceptibility to multiple sclerosis: interactions between conserved extended haplotypes of the MHC and other susceptibility regions.BMC medical genomics · 2021Article
- Inferring disease risk genes from sequencing data in multiplex pedigrees through sharing of rare variants.Genetic epidemiology · 2019Article
- Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients.Journal of neuroinflammation · 2018Article
- Optical coherence tomography segmentation analysis in relapsing remitting versus progressive multiple sclerosis.PloS one · 2017Article
- The Multiple Sclerosis (MS) Genetic Risk Factors Indicate both Acquired and Innate Immune Cell Subsets Contribute to MS Pathogenesis and Identify Novel Therapeutic Opportunities.Frontiers in immunology · 2017Review
- Genetic predictors of relapse rate in pediatric MS.Multiple sclerosis (Houndmills, Basingstoke, England) · 2016Article
- Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis.JAMA neurology · 2016Article
- Whole-Exome Sequencing and Whole-Genome Sequencing in Critically Ill Neonates Suspected to Have Single-Gene Disorders.Cold Spring Harbor perspectives in medicine · 2015Review
- Impact of MS genetic loci on familial aggregation, clinical phenotype, and disease prediction.Neurology(R) neuroimmunology & neuroinflammation · 2015Article
- Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease.Frontiers in immunology · 2015Review
- Precision medicine in chronic disease management: The multiple sclerosis BioScreen.Annals of neurology · 2014Review
- The refinement of genetic predictors of multiple sclerosis.PloS one · 2014Article
- Recent advances and future challenges in the genetics of multiple sclerosis.Frontiers in neurology · 2014Review
- Burden of genetic risk variants in multiple sclerosis families in the Netherlands.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
A previous study using cumulative genetic risk estimations in multiple sclerosis (MS) successfully tracked the aggregation of susceptibility variants in multi-case and single-case families. It used a limited description of susceptibility loci available at the time (17 loci). Even though the full roster of MS risk genes remains unavailable, we estimated the genetic burden in MS families and assess its disease predictive power using up to 64 single-nucleotide polymorphism (SNP) markers according to the most recent literature. A total of 708 controls, 3251 MS patients and their relatives, as well as 117 twin pairs were genotyped. We validated the increased aggregation of genetic burden in multi-case compared with single-case families (P=4.14e-03) and confirm that these data offer little opportunity to accurately predict MS, even within sibships (area under receiver operating characteristic (AUROC)=0.59 (0.55, 0.53)). Our results also suggest that the primary progressive and relapsing-type forms of MS share a common genetic architecture (P=0.368; difference being limited to that corresponding to ± 2 typical MS-associated SNPs). We have confirmed the properties of individual genetic risk score in MS. Comparing with previous reference point for MS genetics (17 SNPs), we underlined the corrective consequences of the integration of the new findings from GWAS and meta-analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.