ReviewPediatric nephrology (Berlin, Germany)2014
Optimizing peritoneal dialysis prescription for volume control: the importance of varying dwell time and dwell volume.
Review in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02748733 (Randomized Cross-over Comparison of Double Mini PET With Standard vs. Adapted Dwell Volume and Dwell Time - Proof of Concept of Adapted PD), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Cross-over Comparison of Double Mini PET With Standard vs. Adapted Dwell Volume and Dwell Time - Proof of Concept of Adapted PD
Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Randomized cross-over comparison of double mini-PET with standard versus adapted dwell volumes and dwell times in children on chronic peritoneal dialysis.Pediatric nephrology (Berlin, Germany) · 2026Trial
- Intraperitoneal pressure measurements in children on peritoneal dialysis: a review and European practice survey.Pediatric nephrology (Berlin, Germany) · 2026Review
- Adequacy of dialysis in children and adolescents: more than just Kt/V.Pediatric nephrology (Berlin, Germany) · 2026Review
- Acute peritoneal dialysis adequacy among children at a national referral hospital in Kenya: a cross-sectional study in a resource-limited setting.BMC nephrology · 2026Article
- Five-Year Time Profiles of Clearances of Different Uremic Solutes in Incident Peritoneal Dialysis Patients.American journal of nephrology · 2025Article
- Relationship between intraperitoneal pressure and the development of hernias in peritoneal dialysis: confirmation for the first time of a widely accepted concept.International urology and nephrology · 2024Observational
- New perspectives in pediatric dialysis technologies: the case for neonates and infants with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024Article
- Assessment and management of fluid overload in children on dialysis.Pediatric nephrology (Berlin, Germany) · 2019Review
- Continuous ambulatory peritoneal dialysis (CAPD) in children: a successful case for a bright future in a developing country.The Pan African medical journal · 2019Article
- Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients.Scientific reports · 2017Article
- Should sodium removal in peritoneal dialysis be estimated from the ultrafiltration volume?Pediatric nephrology (Berlin, Germany) · 2017Review
- Impact of fill volume on ultrafiltration with icodextrin in children on chronic peritoneal dialysis.Pediatric nephrology (Berlin, Germany) · 2016Article
- Is peritoneal dialysis still an equal option? Results of the Berlin pediatric nocturnal dialysis program.Pediatric nephrology (Berlin, Germany) · 2015Article
- Anterior ischemic optic neuropathy in pediatric peritoneal dialysis: risk factors and therapy.Pediatric nephrology (Berlin, Germany) · 2014Article
- Mesenchymal Conversion of Mesothelial Cells Is a Key Event in the Pathophysiology of the Peritoneum during Peritoneal Dialysis.Advances in medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Not only adequate uremic toxin removal but also volume control is essential in peritoneal dialysis (PD) to improve patient outcome. Modification of dwell time impacts on both ultrafiltration (UF) and purification. A short dwell favors UF but preferentially removes small solutes such as urea. A long dwell favors uremic toxin removal but also peritoneal fluid reabsorption due to the time-dependent loss of the crystalloid osmotic gradient. In particular, the long daytime dwell in automated PD may result in significant water and sodium reabsorption, and in such cases icodextrin should be considered. Increasing dwell volume favors the removal of solutes such as sodium due to the increased volume of diffusion and the recruitment of peritoneal surface area. A very large fill volume with too high an intraperitoneal pressure (IPP) may, however, result in back-filtration and thus reduced UF and sodium clearance. Based on these principles and the individual transport and pressure kinetics obtained from peritoneal equilibration tests and IPP measurements, we suggest combining short dwells with a low fill volume to favor UF with long dwells and a large fill volume to favor solute removal. Results from a recent randomized cross-over trial and earlier observational data in children support this concept: the absolute UF and UF relative to the administered glucose increased and solute removal and blood pressure improved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.