ArticleDevelopment (Cambridge, England)2013
Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Zebrafish as a Versatile Model for Cardiovascular Research: Peering into the Heart of the Matter.Cells · 2025Review
- Stage-specific DNA methylation dynamics in mammalian heart development.Epigenomics · 2025Review
- Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure.Nature communications · 2025Article
- Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification.Nature communications · 2023Article
- Tmem88 confines ectodermal Wnt2bb signaling in pharyngeal arch artery progenitors for balancing cell cycle progression and cell fate decision.Nature cardiovascular research · 2023Article
- Towards Understanding the Gene-Specific Roles of GATA Factors in Heart Development: Does GATA4 Lead the Way?International journal of molecular sciences · 2022Review
- Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.Cell reports · 2021Article
- Review
- Exploring the Activities of RBPMS Proteins in Myocardial Biology.Pediatric cardiology · 2019Review
- TMEM88 Inhibits Wnt Signaling by Promoting Wnt Signalosome Localization to Multivesicular Bodies.iScience · 2019Article
- Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome.Cell reports · 2018Article
- Article
- Article
- Deletion of Pr130 Interrupts Cardiac Development in Zebrafish.International journal of molecular sciences · 2016Article
- Transcriptional Regulation of Heart Development in Zebrafish.Journal of cardiovascular development and disease · 2016Article
- Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish.Development (Cambridge, England) · 2014Article
- Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.Development (Cambridge, England) · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Biphasic control of WNT signaling is essential during cardiogenesis, but how the pathway switches from promoting cardiac mesoderm to restricting cardiomyocyte progenitor fate is unknown. We identified genes expressed in lateral mesoderm that are dysregulated in zebrafish when both gata5 and gata6 are depleted, causing a block to cardiomyocyte specification. This screen identified tmem88a, which is expressed in the early cardiac progenitor field and was previously implicated in WNT modulation by overexpression studies. Depletion of tmem88a results in a profound cardiomyopathy, secondary to impaired cardiomyocyte specification. In tmem88a morphants, activation of the WNT pathway exacerbates the cardiomyocyte deficiency, whereas WNT inhibition rescues progenitor cells and cardiogenesis. We conclude that specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT signaling and expand the number of cardiac progenitors. Tmem88a is a novel component of the regulatory mechanism controlling the second phase of biphasic WNT activity essential for embryonic cardiogenesis.
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