ArticleDevelopment (Cambridge, England)2013
Abdominal-B and caudal inhibit the formation of specific neuroblasts in the Drosophila tail region.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Integration of Spatial and Temporal Patterning in the Invertebrate and Vertebrate Nervous System.Frontiers in neuroscience · 2022Review
- The neuroblast timer gene nubbin exhibits functional redundancy with gap genes to regulate segment identity in Tribolium.Development (Cambridge, England) · 2021Article
- Roles ofFrontiers in cell and developmental biology · 2021Review
- Hox Proteins in the Regulation of Muscle Development.Frontiers in cell and developmental biology · 2021Review
- Sequential activation of Notch and Grainyhead gives apoptotic competence to Abdominal-B expressing larval neuroblasts in Drosophila Central nervous system.PLoS genetics · 2020Article
- Dynamics of activating and repressive histone modifications inDevelopment (Cambridge, England) · 2019Article
- The Hox geneDevelopment (Cambridge, England) · 2019Article
- Combinatorial action of Grainyhead, Extradenticle and Notch in regulating Hox mediated apoptosis in Drosophila larval CNS.PLoS genetics · 2017Article
- Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system.FEBS letters · 2016Review
- Gene expression profiles uncover individual identities of gnathal neuroblasts and serial homologies in the embryonic CNS of Drosophila.Development (Cambridge, England) · 2016Article
- Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.PLoS genetics · 2016Article
- Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior.Mechanisms of development · 2015Review
- The study of the Bithorax-complex genes in patterning CCAP neurons reveals a temporal control of neuronal differentiation by Abd-B.Biology open · 2015Article
- Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner.Cell death and differentiation · 2015Article
- Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells.Genetics · 2015Article
- Article
- Hox targets and cellular functions.Scientifica · 2013Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
The central nervous system of Drosophila melanogaster consists of fused segmental units (neuromeres), each generated by a characteristic number of neural stem cells (neuroblasts). In the embryo, thoracic and anterior abdominal neuromeres are almost equally sized and formed by repetitive sets of neuroblasts, whereas the terminal abdominal neuromeres are generated by significantly smaller populations of progenitor cells. Here we investigated the role of the Hox gene Abdominal-B in shaping the terminal neuromeres. We show that the regulatory isoform of Abdominal-B (Abd-B.r) not only confers abdominal fate to specific neuroblasts (e.g. NB6-4) and regulates programmed cell death of several progeny cells within certain neuroblast lineages (e.g. NB3-3) in parasegment 14, but also inhibits the formation of a specific set of neuroblasts in parasegment 15 (including NB7-3). We further show that Abd-B.r requires cooperation of the ParaHox gene caudal to unfold its full competence concerning neuroblast inhibition and specification. Thus, our findings demonstrate that combined action of Abdominal-B and caudal contributes to the size and composition of the terminal neuromeres by regulating both the number and lineages of specific neuroblasts.
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