ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2013
Role of APOE genotype in gait decline and disability in aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Mechanisms of motoric cognitive risk-Hypotheses based on a systematic review and meta-analysis of longitudinal cohort studies of older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Pooled it
- Pooled it
- Pooled it
- The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults.The Journal of frailty & aging · 2019Trial
- Observational
- Review
- Apolipoprotein E e4 Status Predicts Memory Performance and Daily Functioning in Aging Hispanic/Latino Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study.Journal of the American Geriatrics Society · 2024Article
- Physical function is associated with cognitive status, brain amyloid-beta deposition, and blood biomarkers in Chinese Han population.CNS neuroscience & therapeutics · 2024Article
- Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Gait and balance in apolipoprotein Ɛ4 allele carriers in older adults and Parkinson's disease.Clinical parkinsonism & related disorders · 2023Article
- Plasma metabolomics and lipidomics signatures of motoric cognitive risk syndrome in community-dwelling older adults.Frontiers in aging neuroscience · 2022Article
- Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Risk factors for the progression of motoric cognitive risk syndrome to dementia: Retrospective cohort analysis of two populations.European journal of neurology · 2021Article
- The Effects of Tau, Amyloid, and White Matter Lesions on Mobility, Dual Tasking, and Balance in Older People.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Motoric Cognitive Risk Syndrome: Symptoms, Pathology, Diagnosis, and Recovery.Frontiers in aging neuroscience · 2021Review
- Apolipoprotein E Polymorphism and Frailty: Apolipoprotein ε4 Allele Is Associated with Fatigue but Not Frailty Syndrome in a Community-Dwelling Older Population Cohort.The journal of nutrition, health & aging · 2021Article
- Genetic polymorphisms for BDNF, COMT, and APOE do not affect gait or ankle motor control in chronic stroke: A preliminary cross-sectional study.Topics in stroke rehabilitation · 2021Article
- Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults.Ageing research reviews · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesAlthough apolipoprotein E (APOE) genetic variation may influence risk of gait decline and disability in aging through multiple mechanisms, a systematic examination of this relationship has been lacking. Our objective was to quantify the risk of gait decline and disability associated with the APOE ε4 allele in aging.
methodsWe evaluated 627 community-dwelling adults aged 70 and older (white 67.8%) with APOE genotype and quantitative gait measurements participating in the Einstein Aging Study over a median follow-up of 3.0 years. Main outcomes were gait speed decline (cm/s/year) and incident disability.
resultsAPOE ε4 allele frequency was 24.1%. Presence of APOE ε4 was not significantly associated with gait speed decline overall (p = .37) but was associated with faster gait speed decline in older men (estimate: -1.16, 95% CI: -2.31 to -0.01, p = .04). The interaction between the ε4 allele and male sex predicted gait speed decline (estimate: -1.70, 95% CI: -3.33 to -0.07, p = .04). Presence of the APOE ε4 allele was associated with increased risk of disability in older men (HR 3.72, 95% CI: 1.44-9.59, p = .007). Associations of the ε4 allele with study outcomes remained significant even after accounting for several potential confounders including vascular and cognitive status. The strength of the associations was stronger in the white subgroup.
conclusionThis preliminary report suggests that the APOE ε4 allele is associated with increased risk of gait speed decline and disability in older men.
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