ReviewAIDS (London, England)2013
Examining the evidence on the causal effect of HAART on transmission of HIV using the Bradford Hill criteria.
Review in AIDS (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Cost-Effectiveness of the 'One4All' HIV Linkage Intervention in Guangxi Zhuang Autonomous Region, China.PloS one · 2016Trial
- Review
- Understanding clinical outcome measures reported in HIV pregnancy studies involving antiretroviral-naive and antiretroviral-experienced women.The Lancet. Infectious diseases · 2023Review
- Drug Resistance to Integrase Strand-Transfer Inhibitors among HIV-1-Infected Adults in Guangdong, China.Pathogens (Basel, Switzerland) · 2022Article
- Article
- Global, regional and country-level 90-90-90 estimates for 2018: assessing progress towards the 2020 target.AIDS (London, England) · 2019Article
- Health provider training is associated with improved engagement in HIV care among adolescents and young adults in Kenya.AIDS (London, England) · 2019Article
- The causal effect of opioid substitution treatment on HAART medication refill adherence.AIDS (London, England) · 2015Article
- Costs of health resource utilization among HIV-positive individuals in British Columbia, Canada: results from a population-level study.PharmacoEconomics · 2015Article
- Article
- HIV testing behaviors and attitudes among community recruited methamphetamine users in a South African township.AIDS and behavior · 2015Article
- Treatment as prevention--where next?Current HIV/AIDS reports · 2014Review
- Cost-effectiveness analysis along the continuum of HIV care: how can we optimize the effect of HIV treatment as prevention programs?Current HIV/AIDS reports · 2014Review
- Gonadal function and reproductive health in women with human immunodeficiency virus infection.Endocrinology and metabolism clinics of North America · 2014Review
- The HIV epidemic in Southern Africa - Is an AIDS-free generation possible?Current HIV/AIDS reports · 2014Review
- Article
- Emergency Department Strategies to Identify Out-of-Care People Living With HIV: A Critical Step Toward Ending the HIV Epidemic.Journal of the International Association of Providers of AIDS CareReview
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
In recent years, evidence has accumulated regarding the ability of HAART to prevent HIV transmission. Early supportive evidence was derived from observational, ecological and population-based studies. More recently, a randomized clinical trial showed that immediate use of HAART led to a 96% decrease in HIV transmission events within HIV serodiscordant heterosexual couples. However, the generalizability of the effect of HAART, and the population-level impact on HIV transmission continues to generate substantial debate. We, therefore, conducted a review of the evidence regarding the preventive effect of HAART on HIV transmission within the context of the Bradford Hill criteria for causality. Taken together, we find the accumulated evidence supporting HIV treatment as prevention meets each of the Bradford Hill criteria for causality. We conclude that the opportunity cost of inaction while waiting for additional evidence on the generalizability of effect in other risk groups is too high. Efforts should be redoubled to mobilize the financial capital and political will to optimize implementation of HIV Treatment as Prevention strategies on a wide scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.