ArticleBMC medicine2013
Serum concentrations of 25-hydroxyvitamin D and immunoglobulins in an older Swiss cohort: results of the Senior Labor Study.
Article in BMC medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Evaluation of micronutrients in stable COPD patients.Asia Pacific journal of clinical nutrition · 2025Article
- Nutritional Challenges in Nursing Homes: Pilot Study on Macronutrient Intake and Status of Vitamins D and B12.Nutrients · 2024Article
- Complement System Deficiencies in Elite Athletes.Sports medicine - open · 2024Article
- A critical update on the role of mild and serious vitamin D deficiency prevalence and the COVID-19 epidemic in Europe.Nutrition (Burbank, Los Angeles County, Calif.) · 2022Article
- Molecular Mechanisms of Vitamin D-Mediated Immunomodulation.Galen medical journal · 2021Article
- A Potential Role of Vitamin D on Platelet Leukocyte Aggregation and Pathological Events in Sepsis: An Updated Review.Journal of inflammation research · 2021Review
- 'Scientific Strabismus' or two related pandemics: coronavirus disease and vitamin D deficiency.The British journal of nutrition · 2020Article
- Dietary vitamin DNutrition & metabolism · 2018Article
- Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated Syndrome.Frontiers in immunology · 2018Article
- Article
- An Explorative Biomarker Study for Vaccine Responsiveness after a Primary Meningococcal Vaccination in Middle-Aged Adults.Frontiers in immunology · 2017Article
- SENIORLAB: a prospective observational study investigating laboratory parameters and their reference intervals in the elderly.Medicine · 2017Observational
- Correlation of objectively measured light exposure and serum vitamin D in men aged over 60 years.Health psychology open · 2016Article
- Inflammation Thread Runs across Medical Laboratory Specialities.Mediators of inflammation · 2016Review
- Effect of vitamin D level on the immunogenicity to hepatitis B vaccination in dialysis patients.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Observational
- Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits.BMC geriatrics · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D and the components of humoral immunity play important roles in human health. Older people have lower 25-hydroxyvitamin D (25(OH)D) serum levels than younger adults. We aimed to determine the levels of 25(OH)D serum concentrations in healthy senior citizens and to study their relationship to the levels of components of humoral immunity.
methodsA total of 1,470 healthy Swiss men and women, 60 years or older, were recruited for this study. A total of 179 subjects dropped out of the study because of elevated serum concentrations of C-reactive protein. Fasting blood sera were analyzed for 25(OH)D with the high-performance liquid chromatography (HPLC) and for parathyroid hormone (PTH), immunoglobulins and complement C4 and C3 concentrations with immunoassays. The percentage of participants in each of the four 25(OH)D deficiency groups--severely deficient (<10 ng/ml), deficient (10 to 20), insufficient (21 to 29 ng/ml) and normal (>=30 ng/ml)--were statistically compared. The relationship of the major components of the humoral system and age with 25(OH)D levels was also assessed.
resultsAbout 66% of the subjects had insufficient levels of 25(OH)D. Normal levels of 25(OH)D were found in 26.1% of the subjects of which 21% were males and 30.5% were females (total study population). Severely deficient levels of 25(OH)D were found in 7.98% of the total study population. Low levels of 25(OH)D were positively associated with IgG2 (P = 0.01) and with C4 (P = 0.02), yet were inversely related to levels of IgG1 and IgA (P < 0.05) and C3 (P = 0.01). Serum levels of total IgA, IgG, IgG2 and IgG4 peaked together with 25(OH)D during late summer.
conclusionsApproximately two-thirds of the healthy, older Swiss population presented with Vitamin D insufficiency. The incremental shift in IgA and C3 levels might not necessarily reflect a deranged humoral immune defense; however, given the high prevalence of vitamin D deficiency, the importance of this condition in humoral immunity will be worth looking at more closely. This study supports the role of vitamin D in the competent immune system.
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