ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2014
EP4 and EP2 receptor activation of protein kinase A by prostaglandin E2 impairs macrophage phagocytosis of Clostridium sordellii.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Upregulation ofEpigenetics · 2024Article
- SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis.Experimental dermatology · 2023Article
- Article
- Eicosanoid regulation of debris-stimulated metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2.The Journal of experimental medicine · 2020Article
- Decidual stromal cell-derived PGEAmerican journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Prostaglandin EPharmacology & therapeutics · 2018Review
- The prostaglandin EThe Journal of reproduction and development · 2018Article
- Prostaglandins DJournal of lipid research · 2018Article
- Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-γ ligands in a cyclooxygenase-2-dependent manner.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Doxorubicin resistant cancer cells activate myeloid-derived suppressor cells by releasing PGE2.Scientific reports · 2016Article
- Article
- Mono-ethylhexyl phthalate stimulates prostaglandin secretion in human placental macrophages and THP-1 cells.Reproductive biology and endocrinology : RB&E · 2015Article
- MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation.PloS one · 2015Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
problemClostridium sordellii causes endometrial infections, but little is known regarding host defenses against this pathogen. METHOD OF STUDY: We tested the hypothesis that the immunoregulatory lipid prostaglandin (PG) E2 suppresses human macrophage clearance of C. sordellii through receptor-induced increases in intracellular cyclic adenosine monophosphate (cAMP). The THP-1 macrophage cell line was used to quantify C. sordellii phagocytosis.
resultsPGE2 increased cAMP levels, activated protein kinase A (PKA), and inhibited the class A scavenger receptor-dependent phagocytosis of C. sordellii. Activation of the EP2 and EP4 receptors increased intracellular cAMP and inhibited phagocytosis, with evidence favoring a more important role for EP4 over EP2. This was supported by EP receptor expression data and the use of pharmacological receptor antagonists. In addition, the PKA isoform RI appeared to be more important than RII in mediating the suppression of ingestion of C. sordellii.
conclusionThe endogenous lipid mediator PGE2 impairs human innate immune responses against C. sordellii.
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