ArticleFuture microbiology2013
Considerations regarding appropriate sample size for conducting ferret transmission experiments.
Article in Future microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Pre-Exposure Intranasal Treatment with Neomycin Sulfate Reduces Transmission of Influenza B Virus.Antibiotics (Basel, Switzerland) · 2026Article
- Advancing A(H5N1) influenza risk assessment in ferrets through comparative evaluation of airborne virus shedding patterns.Nature communications · 2026Article
- Identification of clinical and virological correlates associated with influenza A candidate vaccine virus (CVV) attenuation in a ferret model.Journal of virology · 2025Article
- Ocular infectivity and replication of a clade 2.3.4.4b A(H5N1) influenza virus associated with human conjunctivitis in a dairy farm worker in the USA: an in-vitro and ferret study.The Lancet. Microbe · 2025Article
- Eleven quick tips to unlock the power of in vivo data science.PLoS computational biology · 2025Article
- Machine learning approaches for influenza A virus risk assessment identifies predictive correlates using ferret model in vivo data.Communications biology · 2024Article
- Optimal thresholds and key parameters for predicting influenza A virus transmission events in ferrets.Npj viruses · 2024Article
- Robustness of the Ferret Model for Influenza Risk Assessment Studies: a Cross-Laboratory Exercise.mBio · 2022Article
- Effects of Buprenorphine Treatment on Influenza Pathogenesis in the Ferret (Comparative medicine · 2022Article
- Secondary infection withFEMS microbes · 2022Article
- Transmissibility and transmission of respiratory viruses.Nature reviews. Microbiology · 2021Review
- Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments.Emerging infectious diseases · 2018Article
- Article
- Using the Ferret as an Animal Model for Investigating Influenza Antiviral Effectiveness.Frontiers in microbiology · 2016Review
- Animal models for influenza virus transmission studies: a historical perspective.Current opinion in virology · 2015Review
- Article
- Animal models for influenza virus pathogenesis, transmission, and immunology.Journal of immunological methods · 2014Review
- Avian influenza A viruses: from zoonosis to pandemic.Future virology · 2014Article
- Ethical alternatives to experiments with novel potential pandemic pathogens.PLoS medicine · 2014Article
- Role of receptor binding specificity in influenza A virus transmission and pathogenesis.The EMBO journal · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evaluation of: Nishiura H, Yen H-L, Cowling BJ. Sample size considerations for one-to-one animal transmission studies of the influenza A viruses. PLoS ONE 8(1), e55358 (2013). There is an urgent need to model in a laboratory setting the capacity of wild-type influenza viruses to transmit between mammals, to determine the molecular determinants and identify biological properties that confer influenza virus transmissibility, and to explore both pharmaceutical and nonpharmaceutical methods to inhibit virus transmission. Owing to its close physiologic match to humans, researchers typically utilize the ferret to measure influenza virus transmissibility. Nishiura et al. highlight the dilemma facing researchers utilizing the ferret transmission model: how to provide high-quality data to guide public health efforts, while ensuring the ethical use of animals in limited-size, individual, one-to-one transmission experiments. However, the responsible interpretation of data generated using this model can overcome this potential limitation. A closer examination of previously published studies utilizing this model as it is currently employed reveals that the 'sample size' of these studies is not always as small as it may appear.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.