ArticleBMC genomics2013
Segmental duplications in the silkworm genome.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A draft genome of Drung cattle reveals clues to its chromosomal fusion and environmental adaptation.Communications biology · 2022Article
- Genome-wide identification of R2R3-MYB family in wheat and functional characteristics of the abiotic stress responsive gene TaMYB344.BMC genomics · 2020Article
- Genome-wide identification of WD40 genes reveals a functional diversification of COP1-like genes in Rosaceae.Plant molecular biology · 2020Article
- Genome-Wide Characterization ofBioMed research international · 2020Article
- Genome-wide identification and analysis of WD40 proteins in wheat (Triticum aestivum L.).BMC genomics · 2018Article
- Genome-Wide Analyses of the NAC Transcription Factor Gene Family in Pepper (Capsicum annuum L.): Chromosome Location, Phylogeny, Structure, Expression Patterns, Cis-Elements in the Promoter, and Interaction Network.International journal of molecular sciences · 2018Article
- Genome-Wide Identification and Characterization of WD40 Protein Genes in the Silkworm, Bombyx mori.International journal of molecular sciences · 2018Article
- Local selection in the presence of high levels of gene flow: Evidence of heterogeneous insecticide selection pressure across Ugandan Culex quinquefasciatus populations.PLoS neglected tropical diseases · 2017Article
- Detection and quantitation of copy number variation in the voltage-gated sodium channel gene of the mosquito Culex quinquefasciatus.Scientific reports · 2017Article
- Segmental duplications: evolution and impact among the current Lepidoptera genomes.BMC evolutionary biology · 2017Article
- Characterization of genome-wide segmental duplications reveals a common genomic feature of association with immunity among domestic animals.BMC genomics · 2017Article
- Genome-wide patterns of genetic variation among silkworms.Molecular genetics and genomics : MGG · 2015Article
- Copy number variations among silkworms.BMC genomics · 2014Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundSegmental duplications (SDs) or low-copy repeats play important roles in both gene and genome evolution. SDs have been extensively investigated in many organisms, however, there is no information about SDs in the silkworm, Bombyx mori.
resultIn this study, we identified and annotated the SDs in the silkworm genome. Our results suggested that SDs constitute ~1.4% of the silkworm genome sequence (≥1 kb in length and ≥90% in the identity of sequence); the number is similar to that in Drosophila melanogaster but smaller than mammalian organisms. Almost half (42%) of the SD sequences are not assigned to chromosomes, indicating that the SDs are challenges for the assembling of genome sequences. We also provided experimental validation of large duplications using qPCR. The analysis of SD content indicated that the genes related to immunity, detoxification, reproduction, and environmental signal recognition are significantly enriched in the silkworm SDs.
conclusionOur results suggested that segmental duplications have been problematic for sequencing and assembling of the silkworm genome. SDs may have important biological significances in immunity, detoxification, reproduction, and environmental signal recognition in the silkworm. This study provides insight into the evolution of the silkworm genome and an invaluable resource for insect genomics research.
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