ArticleTransfusion2014
Microhemodynamic aberrations created by transfusion of stored blood.
Article in Transfusion, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Oxidation Reduction Potential (ORP) is Predictive of Complications Following Pediatric Cardiac Surgery.Pediatric cardiology · 2018Trial
- Effects of storage-aged red blood cell transfusions on endothelial function in hospitalized patients.Transfusion · 2015Trial
- Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis.PloS one · 2015Trial
- Optimal 6-hour window for salvaged mediastinal blood retransfusion after cardiovascular surgery: an in vitro quality and safety analysis.Blood transfusion = Trasfusione del sangueTrial
- Influence of leukocyte adhesion on partitioning of healthy and diabetic red blood cells at vascular bifurcations.Biophysical journal · 2026Article
- A mathematical model of tissue axial and radial diffusion in the microvasculature for intravascular microscopy and phosphorescence quenching data.Computers in biology and medicine · 2024Article
- Application of machine learning in predicting blood flow and red cell distribution in capillary vessel networks.Journal of the Royal Society, Interface · 2022Article
- A computational study of red blood cell deformability effect on hemodynamic alteration in capillary vessel networks.Scientific reports · 2022Article
- Microfluidic Characterization of Red Blood Cells Microcirculation under Oxidative Stress.Cells · 2021Article
- Evaluation of cellular changes in blood stored for transfusion at Bungoma County Referral Hospital, Kenya.The Pan African medical journal · 2021Observational
- Resuscitation From Hemorrhagic Shock With Fresh and Stored Blood and Polymerized Hemoglobin.Shock (Augusta, Ga.) · 2020Article
- Biochemical changes in whole blood stored for transfusion at Bungoma County Referral Hospital, Kenya.African journal of laboratory medicine · 2020Article
- Electron paramagnetic resonance oximetry as a novel approach to monitor the effectiveness and quality of red blood cell transfusions.Blood transfusion = Trasfusione del sangue · 2019Article
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- Quantitative phase imaging of erythrocytes under microfluidic constriction in a high refractive index medium reveals water content changes.Microsystems & nanoengineering · 2019Article
- Microvascular response to transfusion in elective spine surgery.World journal of orthopedics · 2017Article
- Severity of hyperoxia as a risk factor in patients undergoing on-pump cardiac surgery.Acta medica Lituanic · 2017Article
- Rat red blood cell storage lesions in various additive solutions.Clinical hemorheology and microcirculation · 2017Article
- Blood storage alters mechanical stress responses of erythrocytes.Clinical hemorheology and microcirculation · 2017Article
- The mechanical properties of stored red blood cells measured by a convenient microfluidic approach combining with mathematic model.Biomicrofluidics · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundHuman red blood cells (RBCs) can be stored for up to 42 days under controlled conditions. Physical and chemical changes occur during RBC storage, altering their function. This study links stored cell mechanical changes with hemodynamic functional alterations upon transfusion. STUDY DESIGN AND
methodsMechanical properties of fresh and stored RBCs were evaluated in vitro. Their transfusion effects were evaluated in vivo using intravital microscopy of the rat's cremaster muscle preparation. Rats were hemodiluted to 30% hematocrit, to mimic an anemic state before transfusion, and then exchange-transfused with fresh or stored cells.
resultsIn vitro studies on rheology and oxygen affinity of stored cells confirmed previously published results. Storage was found to modify static and dynamic RBC mechanic behavior. After transfusion, systemic hemodynamics were similar for fresh and stored cells; however, microvascular hemodynamics were drastically affected by stored cells. Stored cells reduced blood flow and oxygen delivery. Additionally, the presence of stored cells in circulation affected cell-to-cell and cell-to-wall interactions and affected cell hydrodynamics. Stored cells disrupted the RBC cell-free layer and wall shear stress signals.
conclusionThe reduced cell deformability due to RBC "storage lesions" caused pathologic changes in microvascular hemodynamics, endothelial cell mechanotransduction, and RBC dynamics. Thus, the mechanical changes of blood-banked cells can limit transfusion ability to achieve its intended goal.
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Registered trials
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