ArticleProceedings of the National Academy of Sciences of the United States of America2013
Loss of function of cinnamyl alcohol dehydrogenase 1 leads to unconventional lignin and a temperature-sensitive growth defect in Medicago truncatula.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 142 citations in OpenAlex.
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- Synergetic effect of fungal pretreatment and lignin modification on delignification and saccharification: a case study of a natural lignin mutant in mulberry.Biotechnology for biofuels and bioproducts · 2025Article
- Comparative proteomic and metabolomic analysis of resistant and susceptible Kentucky Bluegrass cultivars in response to infection by powdery mildew.BMC plant biology · 2024Article
- Involvement of MicroRNAs in the Hypersensitive Response of Capsicum Plants to the Capsicum Chlorosis Virus at Elevated Temperatures.Pathogens (Basel, Switzerland) · 2024Article
- Genome-wide characterization and expression analysis of the CINNAMYL ALCOHOL DEHYDROGENASE gene family in Triticum aestivum.BMC genomics · 2024Article
- A Small Auxin-Up RNA Gene,Genes · 2024Article
- Lignin, the Lignification Process, and Advanced, Lignin-Based Materials.International journal of molecular sciences · 2023Review
- Lignocellulose molecular assembly and deconstruction properties of lignin-altered rice mutants.Plant physiology · 2023Article
- H-lignin can be deposited independently of CINNAMYL ALCOHOL DEHYDROGENASE C and D in Arabidopsis.Plant physiology · 2022Article
- Genome-wide analysis of the3 Biotech · 2022Article
- Whole genome duplication of wild-type andFrontiers in plant science · 2022Article
- Climate-responsive DNA methylation is involved in the biosynthesis of lignin in birch.Frontiers in plant science · 2022Article
- Leaf isoprene emission as a trait that mediates the growth-defense tradeoff in the face of climate stress.Oecologia · 2021Article
- A gene-editing/complementation strategy for tissue-specific lignin reduction while preserving biomass yield.Biotechnology for biofuels · 2021Article
- Tailoring renewable materials via plant biotechnology.Biotechnology for biofuels · 2021Review
- Integrated transcriptomic and proteomic analysis reveals the complex molecular mechanisms underlying stone cell formation in Korla pear.Scientific reports · 2021Article
- Identification of heat responsive genes in pea stipules and anthers through transcriptional profiling.PloS one · 2021Article
- Comparative genomic analysis of superoxide dismutase (Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Importance of Lignin Coniferaldehyde Residues for Plant Properties and Sustainable Uses.ChemSusChem · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is considerable debate over the capacity of the cell wall polymer lignin to incorporate unnatural monomer units. We have identified Tnt1 retrotransposon insertion mutants of barrel medic (Medicago truncatula) that show reduced lignin autofluorescence under UV microscopy and red coloration in interfascicular fibers. The phenotype is caused by insertion of retrotransposons into a gene annotated as encoding cinnamyl alcohol dehydrogenase, here designated M. truncatula CAD1. NMR analysis indicated that the lignin is derived almost exclusively from coniferaldehyde and sinapaldehyde and is therefore strikingly different from classical lignins, which are derived mainly from coniferyl and sinapyl alcohols. Despite such a major alteration in lignin structure, the plants appear normal under standard conditions in the greenhouse or growth chamber. However, the plants are dwarfed when grown at 30 °C. Glycome profiling revealed an increased extractability of some xylan and pectin epitopes from the cell walls of the cad1-1 mutant but decreased extractability of others, suggesting that aldehyde-dominant lignin significantly alters cell wall structure.
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