ArticleThe Journal of infectious diseases2013
Noninvasive molecular imaging of tuberculosis-associated inflammation with radioiodinated DPA-713.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 52 citations in OpenAlex.
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- Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs.Nature communications · 2024Observational
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- Imaging-Selected Host Responses in the Context of Infections.The Journal of infectious diseases · 2023Article
- Nucleolin mediates SARS-CoV-2 replication and viral-induced apoptosis of host cells.Antiviral research · 2023Article
- PET/CT imaging of CSF1R in a mouse model of tuberculosis.European journal of nuclear medicine and molecular imaging · 2022Article
- Overview of positron emission tomography in functional imaging of the lungs for diffuse lung diseases.The British journal of radiology · 2022Review
- High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis.The Journal of clinical investigation · 2022Article
- Retention ofACS infectious diseases · 2021Article
- Visualizing the dynamics of tuberculosis pathology using molecular imaging.The Journal of clinical investigation · 2021Review
- Tuberculosis: Role of Nuclear Medicine and Molecular Imaging With Potential Impact of Neutrophil-Specific Tracers.Frontiers in medicine · 2021Review
- Protein and Microbial Biomarkers in Sputum Discern Acute and Latent Tuberculosis in Investigation of Pastoral Ethiopian Cohort.Frontiers in cellular and infection microbiology · 2021Article
- Brain injury and repair after intracerebral hemorrhage: The role of microglia and brain-infiltrating macrophages.Neurochemistry international · 2021Review
- Imaging Bacteria with Radiolabelled Probes: Is It Feasible?Journal of clinical medicine · 2020Article
- Radiotracer Development for Bacterial Imaging.Journal of medicinal chemistry · 2020Review
- Imaging and Characterization of Macrophage Distribution in Mouse Models of Human Prostate Cancer.Molecular imaging and biology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIncreased expression of translocator protein (TSPO) is a feature of microglial and macrophage activation. Since activated macrophages are key components of tuberculosis-associated inflammation, we evaluated radioiodinated DPA-713, a synthetic ligand of TSPO, for in vivo imaging of host response.
methodsMice were infected with aerosolized Mycobacterium tuberculosis and evaluated using whole-body [(125)I]iodo-DPA-713 single-photon emission computed tomography (SPECT). Ex vivo biodistribution and correlative immunofluorescence studies were also performed.
results[(125)I]Iodo-DPA-713 SPECT imaging clearly delineated tuberculosis-associated pulmonary inflammation in live animals. Biodistribution studies confirmed radiotracer specificity for inflamed pulmonary tissues. Immunofluorescence studies demonstrated that TSPO is highly expressed in CD68(+) macrophages and phagocytic cells within tuberculosis lesions and that [(125)I]DPA-713 specifically accumulates within these cells. Coadministration of excess unlabelled DPA-713 abrogated both the SPECT and ex vivo fluorescence signals. Lesion-specific signal-to-noise ratios were significantly higher with [(125)I]iodo-DPA-713 SPECT (4.06 ± 0.52) versus [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET) (2.00 ± 0.28) performed in the same mice (P = .004).
conclusions[(125)I]Iodo-DPA-713 accumulates specifically in tuberculosis-associated inflammatory lesions by selective retention within macrophages and phagocytic cells. [(125)I]Iodo-DPA-713 SPECT provides higher lesion-specific signal-to-noise ratios than [(18)F]FDG PET and may prove to be a more specific biomarker to monitor tuberculosis in situ.
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