ArticleThe Journal of infectious diseases2013
MgrA activates expression of capsule genes, but not the α-toxin gene in experimental Staphylococcus aureus endocarditis.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Hijacking the signal: a critical evaluation of quorum sensing inhibitors as a next-generation approach against Staphylococcus aureus.Cell communication and signaling : CCS · 2026Review
- The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025Review
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- Exploring the potential of isorhapontigenin: attenuatingmSphere · 2024Article
- The major role ofVirulence · 2023Article
- Factors impacting the regulation ofMicrobiology spectrum · 2023Article
- Two Novel Phenylpropanoid Trimers FromFrontiers in chemistry · 2022Article
- Staphylococcus aureus uses the ArlRS and MgrA cascade to regulate immune evasion during skin infection.Cell reports · 2021Article
- Isolating Crucial Steps in Induction of Infective Endocarditis With Preclinical Modeling of Host Pathogen Interaction.Frontiers in microbiology · 2020Article
- MgrA Negatively Impacts Staphylococcus aureus Invasion by Regulating Capsule and FnbA.Infection and immunity · 2019Article
- Mapping the Global Network of Extracellular Protease Regulation in Staphylococcus aureus.mSphere · 2019Article
- Contribution ofInfection and immunity · 2019Article
- MgrA Governs Adherence, Host Cell Interaction, and Virulence in a Murine Model of Bacteremia Due to Staphylococcus aureus.The Journal of infectious diseases · 2019Article
- Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade.PLoS pathogens · 2019Article
- Regulation ofMicrobiology spectrum · 2019Review
- Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States.PloS one · 2019Article
- Reduce, Induce, Thrive: Bacterial Redox Sensing during Pathogenesis.Journal of bacteriology · 2018Review
- Pathogen-related factors affecting outcome of catheter-related bacteremia due to methicillin-susceptible Staphylococcus aureus in a Spanish multicenter study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Observational
- The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression.PLoS pathogens · 2016Article
- MsaB activates capsule production at the transcription level in Staphylococcus aureus.Microbiology (Reading, England) · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStaphylococcus aureus produces numerous virulence factors but little is known about their in vivo regulation during an infection.
methodsThe production of capsule and α-toxin, and the expression of their respective genes, cap5 and hla, were analyzed by comparing CYL11481 (derivative of Newman) and its isogenic regulatory mutants in vitro. The temporal expression of cap5 and hla and the regulatory genes in vivo was carried out using a rat infective endocarditis model.
resultsIn vitro analyses showed that capsule was positively regulated by MgrA, Agr, Sae, ArlR, and ClpC, and negatively by CodY and SbcDC. The α-toxin was positively regulated by MgrA, Agr, Sae, ArlR, and SbcDC but negatively by ClpC and CodY. In vivo analyses showed that cap5 expression correlated best with mgrA expression, whereas hla expression correlated best with sae expression. Mutation in mgrA drastically reduced cap5 expression in vivo.
conclusionsOur results suggest that, in vitro, Agr is the most important regulator for capsule and α-toxin production, as well as for cap5 transcription, but SaeR is the most critical for hla transcription. However, in vivo, MgrA is the major transcriptional regulator of capsule, but not α-toxin, whereas saeR expression correlates best with hla expression.
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