ArticleMolecular reproduction and development
Polarized light microscopy in reproductive and developmental biology.
Article in Molecular reproduction and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 70 citations in OpenAlex.
- Exploring the 3D architecture of brain tissue using digital holographic microscopy.Biomedical optics express · 2026Article
- Characterisation and correction of polarisation effects in fluorescently labelled fibres.Journal of microscopy · 2025Article
- Review
- Fiber architecture in the human ventromedial striatum and its relation with the bed nucleus of the stria terminalis.PloS one · 2025Article
- Label-free biomedical optical imaging.Nature photonics · 2023Article
- An open resource combining multi-contrast MRI and microscopy in the macaque brain.Nature communications · 2023Article
- Effects of formalin fixation on polarimetric properties of brain tissue: fresh or fixed?Neurophotonics · 2023Article
- Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues.bioRxiv : the preprint server for biology · 2023Article
- New horizons in human sperm selection for assisted reproduction.Frontiers in endocrinology · 2023Review
- Quantitative Jones matrix imaging using vectorial Fourier ptychography.Biomedical optics express · 2022Article
- Hair microscopy: an easy adjunct to diagnosis of systemic diseases in children.Applied microscopy · 2021Review
- Label-free microscopy of mitotic chromosomes using the polarization orthogonality breaking technique.Biomedical optics express · 2021Article
- Postnatal structural development of mammalian Basilar Membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuning.Scientific reports · 2021Article
- Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey.Neurophotonics · 2021Article
- Phytoremediation of azo dye methyl red by macroalgae Chara vulgaris L.: kinetic and equilibrium studies.Environmental science and pollution research international · 2020Article
- Birefringence Changes of Dendrites in Mouse Hippocampal Slices Revealed with Polarizing Microscopy.Biophysical journal · 2020Article
- Genetically encoded orientation probes for F-actin for fluorescence polarization microscopy.Microscopy (Oxford, England) · 2019Article
- Diattenuation Imaging reveals different brain tissue properties.Scientific reports · 2019Article
- Microscale Interrogation of 3D Tissue Mechanics.Frontiers in bioengineering and biotechnology · 2019Review
- Diattenuation of brain tissue and its impact on 3D polarized light imaging.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The polarized light microscope reveals orientational order in native molecular structures inside living cells, tissues, and whole organisms. It is a powerful tool used to monitor and analyze the early developmental stages of organisms that lend themselves to microscopic observations. In this article, we briefly discuss the components specific to a traditional polarizing microscope and some historically important observations on: chromosome packing in the sperm head, the first zygote division of the sea urchin, and differentiation initiated by the first asymmetric cell division in the sand dollar. We then introduce the LC-PolScope and describe its use for measuring birefringence and polarized fluorescence in living cells and tissues. Applications range from the enucleation of mouse oocytes to analyzing the polarized fluorescence of the water strider acrosome. We end with new results on the birefringence of the developing chick brain, which we analyzed between developmental stages of days 12-20.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.