ArticleCancer causes & control : CCC2013
Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study.
Article in Cancer causes & control : CCC, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance.Molecules (Basel, Switzerland) · 2018Pooled it
- Association Between Oral Microbiota and Gastrointestinal/Extra-Gastrointestinal Diseases.The Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- The oral microbiome and oral and upper gastrointestinal diseases.Journal of oral microbiology · 2024Review
- Oral Mucosa in Cancer Patients-Putting the Pieces Together: A Narrative Review and New Perspectives.Cancers · 2023Review
- Comparisons of oral, intestinal, and pancreatic bacterial microbiomes in patients with pancreatic cancer and other gastrointestinal diseases.Journal of oral microbiology · 2021Article
- Article
- 43-Year Temporal Trends in Immune Response to Oral Bacteria in a Swedish Population.Pathogens (Basel, Switzerland) · 2020Article
- Profiling the Oral Microbiome and Plasma Biochemistry of Obese Hyperglycemic Subjects in Qatar.Microorganisms · 2019Article
- Cross-sectional association of physical activity and periodontal antibodies.Journal of periodontology · 2018Article
- The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study.Cancer causes & control : CCC · 2017Article
- The Impact of Tobacco Smoking Upon Chronic/Recurrent Tonsillitis and Post Tonsillectomy Bleeding.International archives of otorhinolaryngology · 2017Article
- Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Observational
- Anticancer Effect of Ursodeoxycholic Acid in Human Oral Squamous Carcinoma HSC-3 Cells through the Caspases.Nutrients · 2015Article
- Association between tobacco use and the upper gastrointestinal microbiome among Chinese men.Cancer causes & control : CCC · 2015Article
- Beta-diversity metrics of the upper digestive tract microbiome are associated with body mass index.Obesity (Silver Spring, Md.) · 2015Article
Corrections and comments
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Authors and funding
44 authors at 20 institutions in 12 countries.
Funding
Abstract
backgroundIncreasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria.
methodsData on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured.
resultsIgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL; p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL).
conclusionsOur findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.
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