ArticleThe Laryngoscope2014
Recovery of vibratory function after vocal fold microflap in a rabbit model.
Article in The Laryngoscope, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Functional Analysis of Injectable Substance Treatment on Surgically Injured Rabbit Vocal Folds.Journal of voice : official journal of the Voice Foundation · 2023Article
- Epithelial response to vocal fold microflap injury in a preclinical model.The Laryngoscope · 2023Article
- Voice Handicap Index Changes After Microflap Surgery for Benign Vocal Fold Lesions Are Not Associated With Recommended Absolute Voice Rest Duration.American journal of speech-language pathology · 2022Article
- RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge.BMC genomics · 2020Article
- Investigation of phonatory characteristics using ex vivo rabbit larynges.The Journal of the Acoustical Society of America · 2018Article
- Recovery of Vocal Fold Epithelium after Acute Phonotrauma.Cells, tissues, organs · 2017Article
- In vivo vocal fold cover layer replacement.The Laryngoscope · 2015Article
- A rabbit vocal fold laser scarring model for testing lamina propria tissue-engineering therapies.The Laryngoscope · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectives/hypothesisThe purpose of this study was to evaluate the return of vibratory function and restoration of vibration amplitude and symmetry after vocal fold microflap surgery. STUDY
designProspective in vivo animal model.
methodsMicroflap surgery was performed on 30 New Zealand white breeder rabbits. The left vocal fold received a 3-mm epithelial incision and mucosal elevation, while the contralateral vocal fold was left intact to serve as an internal control. Quantitative analysis of amplitude ratio and lateral phase difference were measured using high-speed laryngeal imaging at a frame rate of 10,000 frames per second from animals undergoing evoked phonation on postoperative days 0, 1, 3, 5, and 7.
resultsQuantitative measures revealed a significantly reduced amplitude ratio and lateral phase difference on day 0 after microflap. These impairments of vibratory function on day 0 were associated with separation of the vocal fold's body-cover layer. Amplitude ratio increased significantly by day 3 after microflap, with further increases in vibration amplitude on days 5 and 7. While the amplitude ratio improved significantly on day 3, lateral phase difference decreased significantly on day 3, and returned to normal on days 5 and 7.
conclusionsHigh-speed laryngeal imaging was used to investigate the natural time course of postmicroflap recovery of vibratory function. Results revealed the restoration of vibration amplitude and lateral phase difference by days 3 to 7 after microflap. The time period of improved vibratory function observed in this study coincides with the end of the well-documented inflammatory phase of vocal fold wound repair. LEVEL OF EVIDENCE: N/A.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.