ReviewCurrent treatment options in oncology2013
Diagnosis and management of paraneoplastic neurologic disorders.
Review in Current treatment options in oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Acute Polyradiculoneuropathy in a Patient With Squamous Cell Carcinoma of the Cervix: A Diagnostic Challenge.Cureus · 2026Article
- Microscopic Primary Tubal Serous Carcinoma With Colon Metastasis and Paraneoplastic Neurological Syndrome: A Case Report.Clinical case reports · 2025Article
- Complexities in the Diagnosis and Management of Anti-Hu Antibody-Associated Paraneoplastic Syndrome.Cureus · 2024Article
- An overview on CV2/CRMP5 antibody-associated paraneoplastic neurological syndromes.Neural regeneration research · 2023Article
- Imaging of central nervous system emergencies in oncology.Emergency radiology · 2023Article
- Four kinds of antibody positive paraneoplastic limbic encephalitis: A rare case report.World journal of clinical cases · 2023Article
- An Intractable Case of Anti-N-methyl-D-aspartate Receptor Encephalitis with Prolonged Hyperammonemia.Journal of neurosciences in rural practice · 2022Article
- Axillary mass in a woman with progressive exertional limbs numbness and fatigue: a case report.Gland surgery · 2021Article
- A Case of Paraneoplastic Myoclonus Attributed to Non-Small Cell Lung Cancer.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Gender issues of antibody-mediated diseases in neurology: (NMOSD/autoimmune encephalitis/MG).Therapeutic advances in neurological disorders · 2020Review
- Secondary Parkinson disease caused by breast cancer during pregnancy: A case report.World journal of clinical cases · 2019Article
- Paraneoplastic limbic encephalitis cured with nephron-sparing surgery in a patient with clear cell renal cell carcinoma: a case report.The Journal of international medical research · 2019Article
- Paraneoplastic sensorimotor polyneuropathy in prostatic adenocarcinoma: A case report.Medicine · 2018Article
- Autoimmune Ataxia During Maintenance Therapy for Acute Lymphoblastic Leukemia.Child neurology open · 2018Article
- Sensory Neuronopathies.Current neurology and neuroscience reports · 2017Review
- Added diagnostic utility of PET in a patient with subacute encephalopathy and small-cell lung cancer.Lung cancer management · 2017Article
- Negative commercial screening test for paraneoplastic antibodies in a case of opsoclonus.Neurology(R) neuroimmunology & neuroinflammation · 2017Article
- The Laboratory Diagnosis of Autoimmune Encephalitis.Journal of epilepsy research · 2016Review
- Severe parkinsonism associated with anti-CRMP5 antibody-positive paraneoplastic neurological syndrome and abnormal signal intensity in the bilateral basal ganglia.Journal of neurology, neurosurgery, and psychiatry · 2016Article
- Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen.Acta neuropathologica · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
opinion statementParaneoplastic neurologic disorders (PND) are a heterogeneous group of immune-mediated neurological disorders associated with systemic cancers. When a PND is diagnosed, prompt identification and treatment of the associated tumor is important as PND stabilization and in some cases improvement have been reported after tumor treatment. The cancer, however, may be small and difficult to detect or the onset of the PND may precede the development of the cancer by months or years. In the latter cases, patients often initially present to neurologists or internists who will need assistance from their oncology colleagues to uncover the cancer. It is therefore important to be aware of the associations of common cancers with specific PND syndromes and the significance in some PND of the presence in serum and/or cerebrospinal fluid (CSF) of specific antineuronal antibodies. Together, this information can focus the search for the tumor or support continued vigilance. Previously thought to be poorly responsive to therapies, it is now recognized that there is a subgroup of PND, mostly associated with antibodies to antigens on the neuronal cell surface that are highly treatment responsive. Treatments aimed at the PND are mostly immunosuppressive and include corticosteroids, plasma exchange and intravenous immunoglobulins (IVIg). Immunosuppressive chemotherapeutics and B-cell targeting drugs such as rituximab also may be useful. Although cancer patients tolerate these therapies, there is the risk of increased toxicity when combined with tumor-directed treatments and treatment plans should be coordinated between specialists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.