ArticleThe Biochemical journal1990
Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets.
Article in The Biochemical journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
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- CAVIN-2 positively correlates with diabetic PAD and promotes LDL transcytosis by inhibiting eNOS activation.Annals of medicine · 2025Article
- Integrative Spatial Omics for Systems-Level Mapping of Pathological Niches.bioRxiv : the preprint server for biology · 2025Article
- Nanobodies against Cavin1 reveal structural flexibility and regulated interactions of its N-terminal coiled-coil domain.Journal of cell science · 2025Article
- Caveolar and non-Caveolar Caveolin-1 in ocular homeostasis and disease.Progress in retinal and eye research · 2022Review
- Caveolin1 Tyrosine-14 Phosphorylation: Role in Cellular Responsiveness to Mechanical Cues.The Journal of membrane biology · 2020Review
- Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice.Haematologica · 2020Article
- Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.Nature communications · 2019Article
- Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis.The Journal of biological chemistry · 2017Article
- Rare coding variants pinpoint genes that control human hematological traits.PLoS genetics · 2017Article
- Downregulation of lncRNA SDPR-AS is associated with poor prognosis in renal cell carcinoma.OncoTargets and therapy · 2017Article
- Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cavin family proteins and the assembly of caveolae.Journal of cell science · 2015Review
- The effect of cell subset isolation method on gene expression in leukocytes.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2014Article
- Seg1 controls eisosome assembly and shape.The Journal of cell biology · 2012Article
- SDPR induces membrane curvature and functions in the formation of caveolae.Nature cell biology · 2009Article
- MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes.The Journal of cell biology · 2009Article
- MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance.Molecular and cellular biology · 2008Article
- Article
- Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the isolation, lipid-binding properties and partial amino acid sequence of PS-p68, a novel 68 kDa phosphatidylserine-binding protein from human platelets. PS-p68 is an abundant constituent of platelets, accounting for 0.5-0.75% of total cell protein. It was purified from platelet cytosol by affinity chromatography. Amino acid sequence analysis yielded no similarity to identified proteins. In contrast with most known phospholipid-binding proteins, PS-p68 does not bind Ca2+ and does not require Ca2+ for its binding of phosphatidylserine. Phosphatidylserine binding to PS-p68 was inhibited by phosphatidic acid and by alkylphospholipids. PS-p68 was isolated as a major phosphoprotein from 32P-labelled platelets and was found to function as a protein kinase C substrate in vitro. However, treatment of intact platelets with phorbol 12-myristate 13-acetate, thrombin or carbacyclin did not increase PS-p68 phosphorylation. Platelets appear to be the only blood cells containing PS-p68, which was not detected in neutrophils, monocytes and lymphocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.