Evidence map›Paper›PMID 23900597›Full record

ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2013

Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage.

Q Liu, M P Gibson, Hongchen Sun, C Qin

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Constructing networks for comparison of collagen types.Journal of integrative bioinformatics · 2024
    Article
  2. Article
  3. Article
  4. Effects ofGlobal medical genetics · 2021
    Review
  5. Dentin Sialophosphoprotein Deletion Leads to Femoral Head Cartilage Attenuation and Subchondral Bone Ill-mineralization.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Accelerated enamel mineralization in Dspp mutant mice.Matrix biology : journal of the International Society for Matrix Biology
    Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Q LiuDepartment of Oral Pathology and Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University, Changchun, China and Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis,Texas A&M University Baylor College of Dentistry, Dallas, Texas.
M P Gibson
Hongchen Sun
C Qin
Texas A&M University · USJilin University · CN

Funding

Studies of the Roles of DMP1 and DSPP in Osteogenesis and DentinogenesisR01DE005092 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI QIN, CHUNLIN · 1985 to 2012
$4.4M
STUDIES OF PROTEINS INVOLVED IN DENTINOGENESISR37DE005092 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BUTLER, WILLIAM T · 1987 to 1996
–
NIDCR NIH HHS DE005092NIDCR NIH HHS R01 DE005092
6 · The paper itself

Abstract

Recently, dentin sialophosphoprotein (DSPP) was found to be expressed in the mandibular condylar cartilage (MCC), but the possible roles of this molecule in the formation, growth, and maintenance of the cartilage are largely unclear. To analyze such roles, we examined Dspp null mice compared with wild-type mice to assess the consequences of Dspp deletion on the morphology and structure of the MCC. Our data showed that DSPP is expressed in the prechondroblastic, chondroblastic, hypertrophic layers of the MCC. Dspp null mice exhibited decreases in the amount of MCC, with reduced formation of articular and prechondroblastic layers in which progenitor cell proliferation levels were distinctly affected. The expression of extracellular matrix molecules, including biglycan and collagen II, IX, and X, was remarkably altered. The findings in this study indicate that continuous DSPP action is required for the growth and/or maintenance of the MCC.

Indexed as

AnimalsBiglycanCartilageCell ProliferationCollagenDentin SialophosphoproteinExtracellular Matrix ProteinsGene DeletionGene Expression RegulationMandibular CondyleMicePhosphoproteinsSialoglycoproteinsStem CellsBiglycanCollagenDentin SialophosphoproteinExtracellular Matrix ProteinsPhosphoproteinsSialoglycoproteinsdentin sialophosphoproteinfibrocartilageknockout micemandibular condylar cartilage

Identifiers

PMID23900597
PMCPMC3788629
OpenAlexW2141040156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.