ArticleDocumenta ophthalmologica. Advances in ophthalmology2013
Retinal structure in vitamin A deficiency as explored with multimodal imaging.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 78 citations in OpenAlex.
- Micronutrient deficiencies in hepatic cirrhosis: Navigating challenges to assessment and implications for clinical management: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Review
- Non neovascular Age - related macular degeneration - Review on clinical and imaging advances.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Reticular pseudodrusen load is associated with an increased risk of stroke.BMJ open ophthalmology · 2026Article
- Longitudinal evaluation of peripheral photoreceptor atrophy in fundus albipunctatus.Japanese journal of ophthalmology · 2026Observational
- Ocular manifestations of vitamin A deficiency in gastrointestinal and hepatobiliary disease.Frontiers in ophthalmology · 2026Article
- Xerophthalmia and Nyctalopia as Presenting Signs of Vitamin A Deficiency in a Patient With Rapid Intentional Weight Loss: A Case Report and Literature Review.Clinical case reports · 2025Article
- Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine.Journal of cardiovascular development and disease · 2025Review
- A preliminary study on digital quantification of ocular attributes in cattle as potential non-invasive indicators of anemia.BMC veterinary research · 2025Article
- Vitamin A deficiency retinopathy in the setting of celiac disease and liver fibrosis.Documenta ophthalmologica. Advances in ophthalmology · 2024Article
- Case of persistent corneal epithelial damage after cataract surgery leading to diagnosis of vitamin A deficiency.Documenta ophthalmologica. Advances in ophthalmology · 2024Article
- Vitamin A deficiency and the retinal "double carrot" sign with optical coherence tomography.Eye (London, England) · 2023Article
- Bilateral compressive optic neuropathy and outer retinopathy due to optic canal hyperostosis in a child with isolated vitamin a deficiency.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Posterior placoid-like maculopathy and macular hole associated with vitamin A deficiency.American journal of ophthalmology case reports · 2023Article
- Correlation between the Serum Concentration of Vitamin A and Disease Severity in Patients Carrying p.G90D inInternational journal of molecular sciences · 2023Article
- A comparison of optophysiological biomarkers of photoreceptor stress and phototoxicity in BALB/cJ, B6 (Cg)-Tyrc-2J/J, and C57Bl/6J mouse strains.Frontiers in ophthalmology · 2023Article
- Documentation of recovery from vitamin A deficiency-related retinopathy via multimodal imaging and electroretinogram testing.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Large Benefit from Simple Things: High-Dose Vitamin A ImprovesInternational journal of molecular sciences · 2022Article
- The Role of Vitamin A in Retinal Diseases.International journal of molecular sciences · 2022Review
- Acquired night blindness due to rod dysfunction after long-term hemodialysis.Japanese journal of ophthalmology · 2022Article
- Reticular Pseudodrusen in Late-Onset Retinal Degeneration.Ophthalmology. Retina · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo define the retinal structural abnormalities in a patient with vitamin A deficiency.
methodsThe patient had a complete ophthalmic examination, electroretinography (ERG), short-wave fundus autofluorescence (SW-AF) and spectral domain optical coherence tomography (SD-OCT) imaging. Serum vitamin A levels were measured.
resultsA 63-year-old man with alcoholic cirrhosis, sclerosing cholangitis and chronic pancreatitis experienced blurred vision and nyctalopia for over a year. There was no family history of eye disorders or consanguinity. His best-corrected visual acuity was 20/20 in each eye; color vision as determined with Ishihara color plates was normal in each eye. Anterior segment examination was unremarkable. He was pseudophakic in both eyes. Standard ERGs showed non-detectable rod function, a cone-mediated dark-adapted response to the standard flash and borderline reduced cone function. Serum vitamin A levels were below 0.06 mg/L (normal 0.3-1.2 mg/L). Fundus examination revealed numerous round yellow-white lesions along the superior arcade and nasal to the optic nerve in both eyes. These lesions were hypoautofluorescent on SW-AF. SD-OCT cross sections demonstrated that they were focal disruptions distal to the ellipsoid band of the photoreceptors with hyperreflective images bulging up the ellipsoid and region. The retinal pigment epithelium and the inner retina appeared intact. Limited and gradual vitamin A supplementation for over a month (20 000 IU/day) led to a dramatic improvement in retinal function and to the resolution of the symptoms. The retinal lesions remained unchanged.
conclusionsImaging of this patient with nyctalopia and severe rod dysfunction suggests that the retinal white lesions known to occur in vitamin A deficiency localize to the photoreceptor layer, particularly the outer segment. On OCT, they are reminiscent of lesions observed in genetic diseases with retinoid cycle dysfunction and of drusenoid subretinal deposits, an abnormality commonly associated with age-related macular degeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.