ArticleScientific reports2013
Force produced after stretch in sarcomeres and half-sarcomeres isolated from skeletal muscles.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
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- Materials science and mechanosensitivity of living matter.Applied physics reviews · 2022Review
- Article
- The effects of inorganic phosphate on muscle force development and energetics: challenges in modelling related to experimental uncertainties.Journal of muscle research and cell motility · 2021Article
- Force Measurements From Myofibril to Filament.Frontiers in physiology · 2021Review
- Sarcomere Length Nonuniformity and Force Regulation in Myofibrils and Sarcomeres.Biophysical journal · 2020Review
- Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities.Scientific reports · 2020Article
- Force-generating capacity of the toe flexor muscles and dynamic function of the foot arch in upright standing.Journal of anatomy · 2019Article
- Titin-mediated thick filament activation stabilizes myofibrils on the descending limb of their force-length relationship.Journal of sport and health science · 2018Article
- Biophysical Tools for Cellular and Subcellular Mechanical Actuation of Cell Signaling.Biophysical journal · 2016Review
- Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations.PLoS computational biology · 2016Article
- The role of sarcomere length non-uniformities in residual force enhancement of skeletal muscle myofibrils.Royal Society open science · 2016Article
- Reduced passive force in skeletal muscles lacking protein arginylation.American journal of physiology. Cell physiology · 2016Article
- The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms.American journal of physiology. Cell physiology · 2016Article
- Residual force depression in single sarcomeres is abolished by MgADP-induced activation.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this study was to evaluate if isolated sarcomeres and half-sarcomeres produce a long-lasting increase in force after a stretch is imposed during activation. Single and half-sarcomeres were isolated from myofibrils using micro-needles, which were also used for force measurements. After full force development, both preparations were stretched by different magnitudes. The sarcomere length (SL) or half-sarcomere length variations (HSL) were extracted by measuring the initial and final distances from the Z-line to the adjacent Z-line or to a region externally adjacent to the M-line of the sarcomere, respectively. Half-sarcomeres generated approximately the same amount of isometric force (29.0 ± SD 15.5 nN·μm(-2)) as single sarcomeres (32.1 ± SD 15.3 nN·μm(-2)) when activated. In both cases, the steady-state forces after stretch were higher than the forces during isometric contractions at similar conditions. The results suggest that stretch-induced force enhancement is partly caused by proteins within the half-sarcomere.
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