ArticleMedical microbiology and immunology2013
Detection of herpesvirus EBV DNA in the lower respiratory tract of ICU patients: a marker of infection of the lower respiratory tract?
Article in Medical microbiology and immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Herpesviridae and Atypical Bacteria Co-Detections in Lower Respiratory Tract Samples of SARS-CoV-2-Positive Patients Admitted to an Intensive Care Unit.Microorganisms · 2024Article
- Reactivation of Epstein-Barr virus among intensive care patients: a prospective observational study.Intensive care medicine · 2024Observational
- Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication.Critical care (London, England) · 2020Article
- Impact of cytomegalovirus load on host response to sepsis.Medical microbiology and immunology · 2019Review
- Characterization of the nasopharyngeal viral microbiome from children with community-acquired pneumonia but negative for Luminex xTAG respiratory viral panel assay detection.Journal of medical virology · 2017Article
- Cytomegalovirus and Epstein-Barr virus reactivation in the intensive care unit.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Observational
- Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS).Medical microbiology and immunology · 2016Article
- Broncholaveolar lavage to detect cytomegalovirus infection, latency, and reactivation in immune competent hosts.Journal of medical virology · 2016Article
- Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome.Intensive care medicine · 2016Article
- Sepsis and cytomegalovirus: foes or conspirators?Medical microbiology and immunology · 2015Review
- Vaccination against infectious diseases: what is promising?Medical microbiology and immunology · 2014Review
- Replacement of biologic by molecular techniques in diagnostic virology: thirty years after the advent of PCR technology-do we still need conventional methods?Medical microbiology and immunology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epstein-Barr virus (EBV) is a lymphotropic herpesvirus causing clinically self-limiting but lifelong persisting infections. Although several severe diseases (e.g., Hodgkin's disease) are associated with EBV, its role in lower respiratory tract infections is still elusive. The prevalence of EBV, herpes simplex virus (HSV) and cytomegalovirus (CMV) in bronchoalveolar fluid (BAL) samples was evaluated in a retrospective study. BAL samples from 135 patients in the intensive or coronary care unit (ICU/ICC) at University Hospital Frankfurt/Main (Germany) were investigated using an in-house real-time PCR to detect EBV-, HSV- and CMV-specific DNA. Overall, herpesvirus DNA was detected in n = 82/135 BAL samples (60.7 %). Besides mono-infections with either EBV or HSV, concomitant infection with EBV and HSV DNA was most frequent, whereby the relative HSV viral load was typically higher. Patients with HSV-positive BAL required mechanical ventilation on average 5 days longer than patients with HSV-negative BAL (p = 0.006). Additionally, the proinflammatory cytokine IL-6 was significantly elevated in sera of patients positive for EBV in comparison with patients with EBV-negative BAL (p = 0.01). This study demonstrates a high prevalence of herpesviruses in BAL samples of ICU/ICC patients. The detection of one or more herpesvirus in BAL is strongly associated with the duration of ventilation and patient's age. The association between IL-6 levels and EBV detection should be evaluated in further studies.
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